系统性糖皮质激素+沙利度胺治疗口咽部重型阿弗他溃疡

The clinical efficacy of systemic corticosteroids and thalidomide for oropharyngeal major recurrent aphthous ulcer

目的评价小剂量系统性糖皮质激素＋沙利度胺治疗口咽部重型阿弗他溃疡（MjAU）的效果。方法92例顽固性口咽部MjAU患者分成两组，治疗组50例，采用小剂量系统性糖皮质激素联合口服沙利度胺治疗；对照组40例，采用单纯中剂量系统性糖皮质激素治疗。结果治疗组病程15～180d，平均（47．80±38．79）d，通过治疗14～41d，平均（22．12±7．39）d后溃疡愈合；对照组病程12～145d，平均（44．62±36．03）d，通过治疗12～36d，平均（19．77±8．92）d愈合。两组治疗效果比较，差异无统计学意义（P〉0．05）。结论小剂量系统性糖皮质激素＋沙利度胺联合治疗与单纯中剂量糖皮质激素治疗顽固性口咽部MjAU有相似的效果。

Objective To evaluate the clinical efficacy of small dose systemic corticosteroids and thalidomide for oro- pharyngeal major recurrent aphthous ulcer （MjAU）. Methods Clinical data of 50 MjAU patients （experimental group）, administered orally with small doses of corticosteroids and thalidomide, and the other 42 MjAU patients （con- trol group） treated only with middle dose corticosteroids were compared. Results In the experimental group, the course was 15-180 days（47.80 ± 38.79） and the ulcers were healed after 14-41 days （22.12 ± 7.39）treatment. In the control group, the course was 12-145 days （44.62 ± 36.03 ）and the ulcers were healed after 12-36 days（ 19.77 ± 8.92） medication. There was no significance between the two groups （ P 〉 0.05 ）. Conclusion Combination of small dose systemic corticosteroids and thalidomide shows similar efficacy as middle dose systemic corticosteroids in the treatment of oropharyngeal MjAU.