原发性开角型青光眼患者血清miR-29b差异性表达

Different expression of miR-29b in serum of primary open-angle glaucoma patients

目的检测散发原发性开角型青光眼(POAG)患者血清miR-29b表达,探讨miR-29b在分子水平致病机制中的作用。方法通过qRT-PCR技术检测并比较20例散发POAG患者及20例健康对照者血清miR-29b表达的差异性。结果散发POAG组血清miR-29b相对表达量是健康对照组的0.15倍,差异有统计学意义(P=0.03)。结论散发POAG组血清miR-29b表达较健康对照组明显下调,提示miR-29b在POAG致病机制中可能起重要作用。

Objective To test the expression of miR-29b in primary open-angle glaucoma（POAG） patients＇ serum and discuss its function in the pathogenesis of POAG. Methods qRT-PCR was used to detect the expression of miR-29b both in 20 sporadic POAG patients and 20 healthy people. The results were compared. Results The expression of miR-29b in sporadic POAG patients was 0.15 times the value of healthy group. The difference was statistically signifi- cant（P = 0.03）. Conclusion The expression of miR-29b in sporadic POAG patients＇ serum was significantly down- regulated, which indicated that miR-29b may play an important role in the pathogenesis of POAG.