长寿命浆细胞与系统性红斑狼疮

Long-lived plasma cells and systemic lupus erythematosus

长寿命浆细胞可长期分泌抗体,产生保护性记忆,参与长期免疫,在自身免疫性疾病(如系统性红斑狼疮)中可持续产生自身抗体,使病情迁延反复复发。长寿命浆细胞主要存在于骨髓,在疾病状态下亦可在脾脏和炎症组织中发现,它能长期存活的原因与微环境中的存活信号因子和表面分化标志物的丢失有关。目前临床上治疗系统性红斑狼疮的药物,大多针对短寿命浆细胞,不能消除长寿命浆细胞。长寿命浆细胞迁移、分化和存活信号分子等可能成为治疗自身免疫性疾病的新靶点。此外,如硼替佐米等新型免疫抑制剂对消除长寿命浆细胞也有一定作用。

long-lived plasma cells can secret antibodies to participate in permanent immunity,and can produce autoantibodies in autoimmune diseases,such as systemic lupus erythematosus （SLE）,which make it deferral and relapse.Survival niches for long-lived plasma cells are provided by bone marrow,and in morbid state also by spleen and inflamed tissues,where survival signal factors are exist,and the down-regulation of many cell surface markers may also contribute to the reason of long-living.Nowadays,drugs used to treat SLE often target to short-lived plasma cells,and can＇t delete longlived plasma cells.The identification of some of the factors involved in the pathways has permitted the development of specific therapeutic approaches and may even provide investigators with further new therapeutic targets,particularly in autoimmune diseases associated with persistent autoantibody production.Some immunosuppressive agents like Bortezomib can eliminate long-lived plasma cells.