阿斯匹林预防性治疗实验性矽肺疗效研究

Effectiveness of preventive administration of aspirin for experimental silicosis

目的 探讨阿斯匹林预防性给药对实验性矽肺的疗效。方法 观察组大鼠染尘 [5 0mg/ (ml·只 ) ]后每次 2 0mg/ml的阿斯匹林溶液 1ml灌胃 ,每周 3次 ,给药 4周后测BALF中细胞总数、巨噬细胞数、中性粒细胞数、淋巴细胞数、细胞内羟脯氨酸含量、血清铜蓝蛋白活性、全肺干重及胶原蛋白含量 ,取肺脏作组织切片 ,观察病理变化。结果 治疗组大鼠所有指标的测定值均显著低于染尘组。结论 阿斯匹林有抑制尘源性炎症和实验性矽肺的纤维化的作用。

Objective To study the effectiveness of preventive administration of aspirin for experimental silicosis.Methods Each of experimental rats was administered intratracheally with one ml of 50 mg/ml of silica suspension to cause experimental silicosis.Then,the rats were administered intra gastrically with one ml of 20 mg/ml aspirin solution thrice a week for four weeks.Total cells,macrophages,neutrophils and lymphocytes in BALF were counted,and intracellular level of hydroxyproline,activity of ceruloplasmin,dry weight and content of collagen of the whole lungs were determined.The lung tissue sections were prepared to observe their pathological changes.Results All the indicators mentioned above were significantly lower in the treatment group than those in the control group.Conclusion Aspirin could inhibit inflammatory response and fibrosis due to silica in the experimental silicosis.