盐酸氨基葡萄糖与对乙酰氨基酚治疗膝骨关节炎的临床疗效观察

Clinical Observation of the Curative Ei cacy of Glucosamine Hydrochloride Capsules and P-acetamidophenol in the Treatment of Knee Osteoarthritis

目的观察盐酸氨基葡萄糖治疗膝骨关节炎的临床效果。方法将2010年10月-2011年12月收治的70例膝骨关节炎患者随机分为观察组和对照组,每组各35例。对照组单纯口服对乙酰氨基酚;观察组在对照组基础上加用盐酸氨基葡萄糖。观察两组临床疗效和不良反应。结果观察组总有效率高于对照组,不良反应发生率低于对照组,两组比较差异均有统计学意义(P<0.05)。结论盐酸氨基葡萄糖治疗膝骨关节炎安全有效。

Objective To observe the clinical effect of glucosamine hydrochloride capsules for the treatment of knee osteoarthritis. Methods We studied 70 cases of knee osteoarthritis in our department from October 2010 to December 2011. The patients were randomly divided into observation group and control group with 35 in each. The control group took P-acetamidophenol orally only and the observation group took glucosamine hydrochloride capsules in addition to P-acetamidophenol. The clinical efficacy and adverse reactions of both two groups were observed. Results Compared with the control group, the effective rate of the observation group was higher and the incidence of adverse reaction was lower （P 〈 0.05）. Conclusion The glucosamine hydrochloride capsules treating knee osteoarthritis is safe and effective.