CA担载姜黄素缓释体系的制备及其缓释动力学

Preparation and Release Kinetics of Curcumin-loaded Electrospun CA Delivery System

采用静电纺丝制备了载药量为20%的多层结构醋酸纤维素/聚乳酸(CA/PLA)载药纳米纤维膜、载药量分别为10%、20%、30%的单层结构CA载药纳米纤维膜,研究了药物姜黄素(CM)与CA间的相互作用,测试了载药膜的释药性能并探讨了其释药动力学模型。结果表明:纤维可纺性良好;傅里叶红外光谱(FT-IR)测试表明CM与CA为纯物理混合;释药性能测试发现,载药量大的纳米纤维释药速率更大,240h内,单层结构载药膜的累积释药率分别为50.6%、58.8%、68.8%;随着PLA层厚度的增加,释药速率减小,240h内,多层结构载药膜的累积释药率分别为55.9%、53.1%、50.8%;可通过改变PLA层厚度控释药物。动力学模型拟合结果显示CM在CA中的释放主要以扩散机制为主,其释放规律更符合Ritger-Peppas释放模型。

A novel drug delivery system （DDS） multi-layer structure cellulose acetate/polylactide（CA/ PLA） nanofiber membranes were prepared by electrospinning, aiming to control the drug release better. Drug of 10% （w/w）, 20% （w/w）, 30% （w/w） were loaded in the single-layer drug-loaded CA membrane, respectively. Similarly, Drug of 20% （w/w） were loaded in the multi-layer drug-loaded CA/PLA membrane. The interaction between drug curcumin （CM） and CA was discussed. Drug release property was investigated and the model of release kinetics was proposed. The experimental results first show that the solution has an excellent spinnability. The Fourier transform infrared spectroscopy （FT-IR） test revealed that CM and CA were well blended physically. Drug release property test found that the more the CM, the greater the drug release rate. Within 240 h, the cumulative drug release rate of single-layer structure drug-loaded membrane were 50.6%, 58.8%, 68.8%, respectively. With the increase of the thickness of PLA layer, the drug release rate decreased. Within 240 h, the cumulative drug release rate of multi-layer structure drug-loaded membrane were 55.9%, 53.1%, 50.8%, respectively. By changing the thickness of the PLA layer, the release of the drug can be controlled. Kinetics model fitting shows that the release of CM in the CA is mainly dominated by diffusion mechanism. Its release pattern is more in accordance with Ritger-Peppas model.