Cajal间质细胞与肠易激综合征关系的研究进展

Relationship between interstitial cells of Cajal and irritable bowel syndrome

Cajal间质细胞(interstitial cells of Cajal,ICC)是胃肠慢波的起搏细胞,具有产生自发电信号、传导慢波电位、调节神经递质等功能,是调节胃肠动力的重要环节.肠易激综合征(irritable bowel syndrome,IBS)是临床上常见的一种消化系统疾病,其发病机制十分复杂,目前主要认为与胃肠运动异常、内脏高敏感、感染、胃肠激素分泌异常等多种因素有关.近年来越来越多的研究表明,IBS存在ICC的形态和数量的异常,ICC与胃肠动力异常、内脏高敏感、感染后IBS以及胃肠激素分泌异常等的发生有一定联系,ICC可能参与IBS的发病过程,本文就二者的关系作一综述.

Interstitial cells of Cajal are the pacemaker of gastrointestinal tract, which can generate elec-trical signals, conduct slow waves and regulate neurotransmitters. Irritable bowel syndrome （IBS） is a common gastrointestinal disease whose pathogenesis is very complicated, involving gas-trointestinal motility disorders, visceral hyper-sensitivity, infection and abnormal secretion of gastrointestinal hormones. In recent years, it has been found that there are associations between interstitial cells of Cajal and gastrointestinal motility disorders, visceral hypersensitivity and abnormal secretion of gastrointestinal hormones. In this paper, we will review the recent progress in understanding the relationship between inter-stitial cells of Cajal and IBS.