原发性闭角型青光眼患者血浆内皮素改变与中医证型关系的研究

A relation between the change of plasma endothelin and the types of traditional Chinese medicine syndrome in the patients with primary angle-closure glaucoma

目的 探讨血浆内皮素与原发性闭角型青光眼发病及中医辨证分型的关系。方法 1 1 5例原发性闭角型青光眼患者中包括慢性闭角型组和急性闭角型组。 2 4例正常志愿受试者作为对照组。根据中医辨证分型的原则分为肝郁气滞证、肝胆火旺证、肝胃虚寒证、阴虚阳亢证 4种证型。应用放射免疫法对青光眼患者和对照组志愿受试者的血浆内皮素含量进行测定。结果 各种类型青光眼患者的血浆内皮素含量均高于对照组 (P <0 0 1 ) ,其中以慢性闭角型患者升高最为显著 ,急性闭角型者次之 ,组内比较差异非常显著 (P <0 0 1 )。 4种证型检测结果比较显示肝郁气滞证患者的升高最为明显 ,其余依次为阴虚阳亢证 ,肝胃虚寒证和肝胆火旺证。组间比较差异有显著意义或非常显著意义 (P <0 0 5或P <0 0 1 )。结论 血浆内皮素与闭角型青光眼的发病有密切的关系 ;

OBJECTIVE To investigate the relationship between the endothelin (ET) and pathological mechanism of primary angle-closure glaucoma (PACG), and the traditional Chinese medicine syndrome. METHODS The One hundred and fifteen patients with PACG were divided into chromic angle-closure group acute angle-closure glaucoma group, and 24 volunteers with normal eyes were as control group. The patients with PACG were classified respectively into ganyuqizhi(肝郁气滞) syndrome, gandanhuewang(肝胆火旺)syndrome, ganweixuihan(肝胃虚寒)syndrome, and yingxuiyangkang(阴虚阳亢)syndrome. The content of ET was measured by relucent immunocompetence in the all patients and the volunteers. RESULTS The content of ET was higher in the patients with PACG groups than the control group ( P <0 01), and it was more obvious in the chromic angle-closure, the acute angle-closure glaucoma group took second place. the difference was significant among the every groups( P <0 01). The data measured were compared among 4 syndromes and the differences were significant between them ( P <0 05 or P <0 01). It was more obvious in the patients with ganyuqizhi syndrome, and in gandanhuewang syndrome, ganweixuihan syndrome, and yingxuiyangkang syndrome it took second places. CONCLUSIONS Content of ET and PACG were close relationship. Content of ET was significant different in each glaucoma groups.