KPC1和胞质p27^(Kip1)在上皮性卵巢癌中的表达及临床意义

Expressions and clinical significance of KPC1 and cytoplasmic p27^(Kip1) in epithelial ovarian cancer

目的:探讨Kip1泛素-促进复合体1(Kip1 ubiquitination-promoting complex 1,KPC1)和胞质p27Kip1在上皮性卵巢癌中的表达及临床意义。方法:免疫组织化学法检测64例上皮性卵巢癌石蜡切片标本中KPC1与胞质p27Kip1的表达,并分析两者与卵巢癌临床病理因素之间的关系。结果:KPC1和胞质p27Kip1表达与组织肿瘤分化程度、FIGO分期、病理类型等有关(P均<0.05)。KPC1与胞质p27Kip1表达呈正相关(r=0.493,P<0.01)。结论:KPC1和胞质p27Kip1在上皮性卵巢癌中协同表达,可能促进卵巢癌的恶性发展。

Objective： To discuss the expressions and significance of Kip1 ubiquitination-promoting complex 1（ KPC1） and cytoplasmic p27Kip1in epithelial ovarian cancer. Methods： The expressions of KPC1 and cytoplasmic p27Kip1in 64 epithelial ovarian cancer samples were detected by immunohistochemical method. The association between their expressions and clinical parameters were analysed. Results：KPC1 and cytoplasmic p27Kip1expressions were associated with the degree of neoplasm differentiation,FIGO staging and pathological types（ both P 0. 05）. Spearman＇s correlation analysis showed KPC1 expression was positively associated with cytoplasmic p27Kip1（ r =0. 493,P 0. 01）. Conclusion： KPC1 and cytoplasmic p27Kip1might play a synergy role in the oncogenesis and development of ovarian cancer.