鼻咽癌后程加速超分割放疗并用安卡治疗研究

The Study on Late Course Accelerated Hyperfraction Radiotherapy in Combination with ANKA in Nasopharyngeal Carcinoma

目的 :比较后程加速超分割放疗并用安卡治疗与常规放疗 ,常规放疗并用安卡治疗鼻咽癌的效果及毒副作用。方法 :将 96例鼻咽癌随机分为 3组 ,常规放疗组 (常放组 )、常规放疗加用安卡组 (药放组 )、后程加速超分割放疗并用安卡组 (后程组 ) ,3组病例肿瘤量相同。结果 :放疗结束时鼻咽癌原发灶全消率 ,常放组、药放组和后程组分别为 62 .5%、83.3%、82 .4 %。半年复查 ,3组全消率分别为68 8%、86.7%、91.2 % ,后程组明显高于常放组P <0 .0 5。CT检查颈部转移淋巴结消退情况与上述结果相似。毒副作用较常规组略重 ,尚可耐受。结论 :后程组较常放组比较肿瘤全消率明显提高 ,毒副作用尚可耐受 。

Objective:To evaluate the efficacy of late course accelerated hyperfraction radiotherapy in combination with ANKA in nasopharygeal carcinoma.Methods:96 patients with nasopharyngeal Carcinmoa were randomized into three groups:the conventional fraction radiotherapy group(CFR),coventional fraction radiotherapy in combination with ANKA group(CFRA),late course accelerated hyperfraction radiotherapy in combination with ANKA group(LFRA) all of the three groups equally received total doses.Results:The local tumor CR rate was respectively 62.5%,83.3%,82.4% at the end of radiotherapy.The local tumor CR rate was raspectively 68.8%,86.7%,91.2%,half year after radiotherapy.The local tumor CR rate in LFRA group was much better than CFR group( P <0.05).The cervical lymph node CR rate showed by CT was similar to above mentioned result.The acute reactions were slightly increased in the LFRA patients.Conclusions:The CR rate of patient with nasopharyngeal carcinoma can be significantly increased by LFRA.The reaction of the LFRA treatment can be tolerated.