摘要
目的动态观察氧化低密度脂蛋白(Ox-LDL)、血栓前体蛋白(TpP)在急性脑梗死中的表达,并探讨其临床意义。方法采用酶联免疫吸附试验(ELISA)法测定44例脑梗死患者(脑梗死组)急性期、恢复期及30例健康对照者(对照组)血清OxLDL及血浆TpP水平,并对脑梗死患者行美国国立卫生研究院卒中量表(NIHSS)评分,分析Ox-LDL、TpP在急性脑梗死中的表达与NIHSS评分的关系。结果脑梗死患者血清Ox-LDL和血浆TpP均较对照组升高,急性期Ox-LDL及TpP显著高于恢复期及对照组,差异具有统计学意义(P<0.01);脑梗死组TpP含量与NIHSS评分呈正相关(P<0.01),Ox-LDL含量高低与NIHSS评分无关(P>0.05);脑梗死组Ox-LDL与TpP水平呈正相关(r=0.521,P<0.05)。结论脑梗死患者血清Ox-LDL、血浆TpP表达上调,且其水平随临床病程不同而发生变化,它们可能协同参与了急性脑梗死的发生、发展;血浆TpP可能与脑梗死的严重程度相关,或可作为急性脑梗死病情及预后判断的指标。
Objective Dynamic observation of oxidized low density lipoprotein(Ox-LDL) and thrombus precursor protein(TpP) expressed in patients with acute cerebral infarction ,and explore its clinical significance .Methods To detect the Ox-LDL and the plasma TpP level of 44 patients with acute cerebral infarction (ACI)respectively in acute stage and recovery stage ,and the healthy 30 cases (control group)by using enzyme-linked immunosorbent assay (ELISA) method ,and all the ACI cases were scored by the national institutes of health stroke scale (NIHSS) .To analyze the expression of Ox-LDL and plasma TpP in patients with ACI ,and the relationship with the NIHSS score .Results Ox-LDL and plasma TpP in patients with ACI all increased compared with the con-trol group .Ox-LDL and TpP in acute stage were significantly higher than the corresponding recovery stage and the control group , the difference was statistically significant (P〈0 .01) .The levels of plasma TpP were positively correlated with the NIHSS score (P〈0 .01) ,and Ox-LDL levels were uncorrelated with the NIHSS score (P〉0 .05) .The levels of Ox-LDL were positively correla-ted with TpP in ACI group (r=0 .521 ,P〈0 .05) .Conclusion The expression of Ox-LDL and plasma TpP in ACI were increased , Ox-LDL and plasma TpP level in ACI varies with changes of clinical course ,and maybe involved in the coordination and the devel-opment process of ACI ;Plasma TpP may be relevant to the seriousness of cerebral infarction ,and may be arguably used as the measurement of ACI patient′s conditions as well as the prognosis estimation .
出处
《重庆医学》
CAS
CSCD
北大核心
2013年第36期4377-4379,共3页
Chongqing medicine
基金
国家自然科学基金资助项目(81100891)
关键词
脑梗死
氧化低密度脂蛋白
血栓前体蛋白
brain infarction
oxidized low density lipoprotein
thrombus precursor protein