氧化低密度脂蛋白和血栓前体蛋白与急性脑梗死的相关性研究

Analysis of correlation between oxidized low density lipoprotein and thrombus precursor protein with acute cerebral infarction

目的动态观察氧化低密度脂蛋白(Ox-LDL)、血栓前体蛋白(TpP)在急性脑梗死中的表达,并探讨其临床意义。方法采用酶联免疫吸附试验(ELISA)法测定44例脑梗死患者(脑梗死组)急性期、恢复期及30例健康对照者(对照组)血清OxLDL及血浆TpP水平,并对脑梗死患者行美国国立卫生研究院卒中量表(NIHSS)评分,分析Ox-LDL、TpP在急性脑梗死中的表达与NIHSS评分的关系。结果脑梗死患者血清Ox-LDL和血浆TpP均较对照组升高,急性期Ox-LDL及TpP显著高于恢复期及对照组,差异具有统计学意义(P<0.01);脑梗死组TpP含量与NIHSS评分呈正相关(P<0.01),Ox-LDL含量高低与NIHSS评分无关(P>0.05);脑梗死组Ox-LDL与TpP水平呈正相关(r=0.521,P<0.05)。结论脑梗死患者血清Ox-LDL、血浆TpP表达上调,且其水平随临床病程不同而发生变化,它们可能协同参与了急性脑梗死的发生、发展;血浆TpP可能与脑梗死的严重程度相关,或可作为急性脑梗死病情及预后判断的指标。

Objective Dynamic observation of oxidized low density lipoprotein（Ox-LDL） and thrombus precursor protein（TpP） expressed in patients with acute cerebral infarction ,and explore its clinical significance .Methods To detect the Ox-LDL and the plasma TpP level of 44 patients with acute cerebral infarction （ACI）respectively in acute stage and recovery stage ,and the healthy 30 cases （control group）by using enzyme-linked immunosorbent assay （ELISA） method ,and all the ACI cases were scored by the national institutes of health stroke scale （NIHSS） .To analyze the expression of Ox-LDL and plasma TpP in patients with ACI ,and the relationship with the NIHSS score .Results Ox-LDL and plasma TpP in patients with ACI all increased compared with the con-trol group .Ox-LDL and TpP in acute stage were significantly higher than the corresponding recovery stage and the control group , the difference was statistically significant （P〈0 .01） .The levels of plasma TpP were positively correlated with the NIHSS score （P〈0 .01） ,and Ox-LDL levels were uncorrelated with the NIHSS score （P〉0 .05） .The levels of Ox-LDL were positively correla-ted with TpP in ACI group （r=0 .521 ,P〈0 .05） .Conclusion The expression of Ox-LDL and plasma TpP in ACI were increased , Ox-LDL and plasma TpP level in ACI varies with changes of clinical course ,and maybe involved in the coordination and the devel-opment process of ACI ;Plasma TpP may be relevant to the seriousness of cerebral infarction ,and may be arguably used as the measurement of ACI patient′s conditions as well as the prognosis estimation .