金尔伦治疗急性脑梗死的疗效研究

Study of the efficacy of naloxone in treatment of acute cerebral infarction

目的 :了解急性脑梗塞患者红细胞免疫粘附 (red cellimmuneadherence ,RCIA)功能的变化及纯阿片受体拮抗剂金尔伦对其影响。方法 :以郭峰法测定 49例急性脑梗塞患者和 30例健康体检者红细胞补体C3b受体花环率 (RBC C3bRR)和红细胞免疫复合物花环率 (RBC ICR) ,并给 2 5例急性脑梗塞患者以金尔伦治疗 2周后复测RBC C3bRR和RBC ICR。结果 :脑梗塞急性期患者RBC C3bRR明显降低 ,RBC ICR明显增高 ;金尔伦治疗 2周后 ,RBC C3bRR明显增高 ,RBC ICR明显降低 ,肢体功能也明显提高 ,与对照组比较差异显著 (P <0 .0 1)。结论 :RCIA功能的变化与急性脑梗塞的发生发展有密切关系 。

Objective:To observe changes of red cell immune adherence(RCIA)in patients with acute cerebral infarction (ACI) and the influence of naloxone on them.Methods:The RBC C 3bRR and RBC ICR contents in 49 ACI patients and in 30 healthy people were measured.After that 25 of the ACI patients were treated with naloxone for 2 weeks,and their RBC Cb 3RR and RBC ICR contents were measured again.Results:The content of RBC C 3bRR was significantly decreased and the content of RBC ICR was significantly increased in stage of attack of ACI.After 2 weeks treatment with naloxone the results were reversed with increased RBC C 3bRR and decreased RCB ICR.Conclusions:There are closely related relationship between changes in RCIA function and ACI attack.Naloxone in early stage can enhance RCIA function and improve limb functon of the patients. [