阿立哌唑与利培酮治疗精神分裂症对照研究

Comparative study of Aripiprazole and Risperidone in the treatment of schizophrenia

目的:比较阿立哌唑与利培酮治疗精神分裂症的临床疗效和不良反应。方法:将95例精神分裂症患者随机分为两组,分别给予阿立哌唑(阿立哌唑组)与利培酮(利培垌组)治疗12周。用阳性和阴性综合征量表(PANSS)和治疗中需处理的不良反应症状量表(TESS)作为评定指标,分别于治疗前后评定疗效和不良反应。结果:阿立哌唑组总有效率和临床治愈率分别为79.74%、56.67%,明显高于利培酮组的61.05%、29.47%,两组PANSS评分治疗后均显著下降(P<0.01),阿立哌唑组治疗中减分率及治疗中的不良反应明显低于利培酮组(P<0.05)。结论:在精神分裂症的治疗中,阿立哌唑的总有效率、治愈率优于利培酮,且不良反应低、依从性好。

Objective： To compare the efficacy and adverse reactions of Aripip^azole and Risperidone in the treatment of schizophrenia. Meth- ods：95 patients with schizophrenia were randomly divided into two groups ,were given Aripiprazole or Risperidonefor treatment of 12 weeks. The Positive and Negative Syndrome Scale （PANSS） and the Treatment Emergent Side Effect Scale （TESS） were used to assess the clinical efficacy and the adverse reaction respectively before and after the treatment. Results： The total efficiency rates and the clinical cure rate in the Aripiprazole group were 79.74% and 56.67% respectively, obviously higher than those in the Risperidone group （61.05 % and 29.47 % ）, two groups of PANSS score were significantly de- creased after treatment （P 〈 0.01 ）, in the treatment, the reduction rate and adverse reaction of the Aripiprazole group were obviously higher than the Ris- peridone group （ P 〈 0.05 ）. Conclusion ： In the treatment of schizophrenia, the total efficiency rates and the clinical cure rate of Aripiprazole were better than Risperidone, and has low adverse reactions and good compliance.