稳定型心绞痛患者冠状动脉侧支循环形成与PD-ECGF的相关性研究

Study on the Correlation Between Coronary Collateral Circulation Formation and PD-ECGF in Patients with Stable Angina Pectoris

[目的]探讨冠状动脉严重狭窄患者的冠状动脉侧支循环（CCC ）形成与血小板源性内皮细胞生长因子（PD-ECGF）浓度的关系。[方法]入选冠状动脉造影术左前降支、左回旋支和右冠状动脉中至少1支狭窄≥90％的患者55例，按照Rentrop分级方法，对CCC进行分级：0级16例，1级14例，2级15例，3级10例；采用酶联免疫吸附法检测患者 PD-ECGF浓度；应用Gensini积分系统评价患者的冠状动脉粥样硬化病变程度。[结果]0和1级组血清PD-ECGF水平明显低于2和3级组。CCC分级与血清PD-ECGF浓度水平呈正相关（r＝0．86， P＜0．01）。血清PD-ECGF浓度与Gensini积分呈正相关（r＝0．93，P＜0．01）。[结论]冠状动脉严重狭窄患者，随着血清PD-ECGF浓度增加，其侧支循环越发达，因此PD-ECGF可能促进了CCC的生成。

[Objective]To explore the correlation between coronary collateral circulation （CCC） formation and platelet derived endothelial cell growth factor（PD-ECGF） level .[Methods] A total of 55 patients with at least 1 vessel in left anterior descending branches ,left convolution branches and right coronary arteries by cor-onary angiography were enrolled .According to Rentrop grading method ,CCC was classified into grade 0（ n=16） ,grade 1（ n=14） and grade 3（ n=10） .Enzyme linked immunosorbent assay（ELISA） was used to detect PD-ECGF level .Gensini＆#39;s score system was used to evaluate the extent of coronary artery atherosclerosis .[Results] Serum levels of PD-ECGF in the groups with grade 0 and grade 1 were lower than those in the groups with grade 2 and grade 3 .CCC grade was positively correlated with serum PD-ECGF level（r=0 .86 ,P＆lt;0 .01） .Serum PD-ECGF level was positively correlated with Gensini＆#39;s score（r=0 .93 ,P＆lt;0 .01） .[Conclu-sion]CCC is more developed with the increasing of serum PD-ECGF level in patients with severe coronary ar-tery stenosis .Therefore PD-ECGF may promote the formation of CCC .