恶性骨肿瘤中XIAP和Caspase-3的表达及临床意义

Expression and clinical significance of XIAP and Caspase-3in malignant bone tumors

目的研究恶性骨肿瘤中X染色体连锁凋亡抑制蛋白(X-linked inhibitor of apoptosis protein,XIAP)、天冬氨酸特异性的半胱氨酸蛋白酶-3(Caspase-3)的表达情况,探讨XIAP、Caspase-3在恶性骨肿瘤发生发展中可能的作用及临床意义。方法免疫组织化学法对35例恶性骨肿瘤标本及15例良性骨肿瘤标本分别检测XIAP及Caspase-3的表达。结果恶性骨肿瘤组织中XIAP表达的阳性率高于良性骨肿瘤组织(χ2=4.126,P<0.05);而Caspase-3表达的阳性率低于良性骨肿瘤组织(χ2=4.778,P<0.05)。恶性骨肿瘤组织中XIAP与Caspase-3的表达评分呈负相关(r=-0.352,P<0.05)。结论 XIAP和Caspase-3可能与恶性骨肿瘤的发生、发展有一定的关系,为临床提供新的诊治思路。

Objective hibitor of apoptosis protein To explore the possible role and clinical significance of X-linked in- （XIAV） and Caspase-3 in bone malignant tumors by examining the ex- pression of XIAP and Caspase-3. Methods The expression of XIAP and Caspase-3 in 35 malignant bone tumor tissues and 15 bone benign tumor tissues were detected by immunohistochem- istry method. Results The positive rate of XIAP expression in tissues of malignant bone tumors was significantly higher than that in benign bone tumor tissues（x^2=4.126,P〈0.05） while the positive rate of Caspase-3 expression was significantly lower（x^2=4.778,P〈0.05）. There was negatively relationship between the score of XIAP and Caspase-3 expression （r=-0.352, P〈0.05）. Conclusion XIAP and Caspase-3 may be associated with the occurrence and development of malignant bone tumors, which provides ideas to the clinical diagnosis and treatment.