参麦注射液不良反应52例分析

Analysis of 52 adverse reaction cases of Dansen injection

目的研究参麦注射液临床应用过程中出现的不良反应的特点,为临床用药提供依据。方法对2006年1月至2012年12月在我院收集的参麦注射液治疗的52例患者进行了研究,统计分析这些患者年龄、性别分布,原发疾病类型,出现药物不良反应的时间以及药物不良反应的类型与临床表现。结果随着年龄的增加,不良反应发生率明显升高,且女性比例明显高于男性,差异有统计学意义(P<0.05);52例患者中原发疾病以休克、病毒性心肌炎、冠心病和慢性肺心病为主;与用药后出现不良反应的例数比较,用药过程中出现不良反应的患者比例更大,差异有统计学意义(P<0.05),且10 min内出现反应的比例最高;不良反应类型及临床表现比较,过敏反应与心血管系统占50%以上,以皮肤瘙痒、心悸、胸闷、过敏性休克等临床表现居多。结论临床使用参麦注射液的过程中,要结合患者的年龄及性别给予不同的关注,需要了解患者原发疾病,采用不同的时间点进行重点观察,并针对临床常见的不良反应类型准备好必要的抢救及护理措施。

Objective To study the characteristic of adverse effects of Dansen injection in clinical application and offer a basis for clinical medication. Methods From January of 2006 to December of 2012, 52 patients treated with Dansen injection were enrolled in this study. Data of age, sex distribution, primary disease types, time of adverse reaction emergency and types and clinical manifestation of adverse reactions were analyzed. Results The incidence of adverse re- actions rose along with the increase of age, and it was higher among females than males; the differences were statistically significant（P〈0.05）. Shock, viral myocarditis, coronary heart disease and chronic corpulmonale were common primary diseases among 52 patients. The adverse reac- tions more commonly emerged in the process of using drug than after drug treatment （P〈0.05）; the most high risk time was about 10 min after injection. In terms of the types and clinical manifestation of adverse reactions, allergic reactions and cardiovascular system symptoms took a large portion as more than 50% in all adverse effects; the common clinical manifestations were skin pruritus, palpitation, chest tightness, anaphylactic shock. Conclusion In the process of the Danshen injection, patients＇ age, gender, primary diseases should be taken into consideration; at the high risk time zone the patients should be observed carefully; the necessary rescue and nursing measures should be prepared for different types of common adverse reactions.