105例儿童抽动障碍临床资料分析及中药疗效观察

Analysis of Clinical Data and Clinical Efficacy of Traditional Chinese Medicine Treatment in Children with Tic Disorder:A Report of 105 Cases

目的了解儿童抽动障碍的临床特点及中医证型分布,观察中药治疗儿童抽动障碍的临床疗效。方法以确诊为抽动障碍的105例儿童作为研究对象,进行临床分析。在停用所有西药2周后,予自拟抽动1号方加减治疗3个月,观察疾病疗效和中医证候疗效。结果 105例儿童抽动障碍的临床表现多样化,误诊率高达57.1%,中医证型分布以肝亢风动型最多,自拟抽动1号方治疗儿童抽动障碍的总有效率达93.3%,随访1年后复发率为21.9%。结论具有平肝熄风、镇静止痉功效的自拟抽动1号方对儿童抽动障碍有较好疗效,且无明显不良反应。

Objective To investigate the clinical features and traditional Chinese medicine （TCM） syn- drome types of tic disorder in children and to observe the clinical efficacy of TCM treatment in children with tic disorder. Methods Analysis was performed on the clinical manifestations, misdiagnosis, and TCM syndrome types of 105 children with tic disorder. Two weeks after Western medicine treatment, the patients were treated with modified self-made No. 1 Prescription for tic disorder for 3 months. The disease outcome and TCM syndrome outcome were evaluated. Results The 105 children with tic disorder had di- verse clinical manifestations. The misdiagnosis rate was 57.1%. Stirring of wind due to liver hyperactivity was the dominant TCM syndrome type in these patients. The overall response rate of the patients treated with self made No. 1 Prescription for tic disorder was 93.3%, and the recurrence rate was 21.9% during one-year follow-up. Conclusion Self-made No. 1 Prescription for tic disorder, which is capable of calming the liver to stop the wind and has sedative and spasm-relieving effects, has good clinical efficacy in children with tic disorder and causes no obvious adverse reactions.