电针结合磁刺激治疗对脊髓损伤尿潴留大鼠排尿功能的影响

Effect of electroacupuncture combined magnetic stimulation therapy on urinary function of urinary retention rats with spinal cord injury

目的:观察脊髓损伤尿潴留模型大鼠排尿功能相关指标的变化,探讨电针及骶神经根磁刺激治疗脊髓损伤早期尿潴留的作用机制。方法:SD大鼠50只随机分为正常组、模型组、电针组、磁刺激组和联合组各10只,采用重物坠落打击方法制备脊髓损伤模型,模型组仅造模不治疗,正常组不造模不治疗,电针组采用电针治疗,磁刺激给予磁刺激治疗,联合组采用电针及磁刺激治疗。测定各组大鼠膀胱最大容量、漏尿点压力和膀胱顺应性。结果:治疗10次后,模型组膀胱最大容量、膀胱顺应性明显高于其他4组(P<0.05),联合组则低于电针及磁刺激组(P<0.05);模型组膀胱漏尿点压力明显低于其他4组(P<0.05),联合组则高于电针及磁刺激组(P<0.05);电针及磁刺激组比较差异无统计学意义。结论:电针及骶神经根磁刺激治疗均能改善脊髓损伤后早期尿潴留状况,而联合治疗效果更好。

Objective：To observe the changes of urinary function in rat urinary retention model with spinal cord injury,and explore the action mechanism of electroacupuncture and magnetic stimulation of the sacral nerve roots for urinary intenstion in early spinal cord injury.Methods：Fifty SD rats were randomly divided into 5 groups：normal group,model group,electroacupuncture group,magnetic stimulation group,and combination therapy group （n=10 each）.The spinal cord injury model was established by the heavy objects falling method.The rats in model group were subjected to modeling only without any treatment,those in normal group were not subjected to modeling and treatmen,those in electroacupuncture group given electric acupuncture,and those in magnetic stimulation group were treated by magnetic stimulation.The rats were anesthetized by intraperitoneal injection of chloral hydrate.Rat bladder capacity,leakage point pressure and bladder compliance were measured.Results：After treatment for 10 times,the bladder capacity and bladder compliance in the model group were significantly increased as compared with other groups （P＜0.05）,and those in the combination therapy group were significantly reduced as comapred with the electroacupuncture group and the magnetic stimulation group （P＜0.05）.The leakage point pressure in the model group was significantly lower than other groups （P＜0.05）,and that in the combination therapy group was significantly lower than the electroacupuncture group and the magnetic stimulation group （P＜0.05）.Conclusion：Both electroacupuncture and magnetic stimulation therapy could significantly alleviate the urinary retention in early spinal cord injury,and electroacupuncture combined with magnetic stimulation treatment can obtain more satisfactory effectiveness.