噻托溴铵治疗慢性阻塞性肺疾病稳定期患者48例临床观察被引量：6

Clinical observation of tiotropium bromide for COPD stationary phase (48 cases report) .

下载PDF

导出

摘要目的探讨噻托溴铵吸入剂在慢性阻塞性肺疾病(COPD)稳定期患者的疗效。方法将100例COPD稳定期患者随机分为两组,治疗组48例给予噻托溴铵吸入治疗(18μg,1次/d),对照组52例不作任何治疗。比较两组治疗1、2、6个月后FEV1、FVC。结果治疗组患者FEV1、FVC明显改善,优于对照组,P<0.05。结论噻托溴铵吸入剂可改善COPD稳定期患者的肺通气功能,从而提高患者生活质量,减少急性发作,值得临床推广应用。 Objective To discuss the curative effect of tiotropium bromide inhalant on patients suffering COPD in the sta- tionary phase. Methods 100 cases were randomly divided into the treatment group and the control group. The control group were not accepted any treatment, while the treatment group were treated with tiotropium bromide inhalant （18μg, I/d）. FEV1, FVC were compared after 1, 2, 6 months. Results FEV1 and FVC of the treatment group were better than that of the control group, P 〈0. 05. Conclusion Tiotropium bromide inhalant could improve the pulmonary ventilation function of COPD patients in the stationary phase.

作者杨林

机构地区梓潼县人民医院呼吸内科

出处《四川医学》 CAS 2013年第8期1214-1216,共3页 Sichuan Medical Journal

关键词噻托溴铵慢性阻塞性肺疾病肺功能 tiotropium bromide COPD lung function

分类号 R563.9 [医药卫生—呼吸系统]

引文网络
相关文献

参考文献7

1金方强,王辉.噻托溴铵吸入治疗对稳定期COPD患者肺功能的影响[J].浙江临床医学,2008,10(7):950-951. 被引量：24
2慢性阻塞性肺疾病诊治指南(2007年修订版)[J].中华结核和呼吸杂志,2007,30(1):8-17. 被引量：8234
3Zielinski J, Bednarek M, Gorecka D, et al. Increasing COPD aware- ness[J]. Eur Respir J, 2006, 27(4) : 833 -852.
4郑劲平,康健,蔡柏蔷,周新,曹兆龙,白春学,钟南山.吸入噻托溴铵干粉与异丙托溴铵定量气雾剂治疗慢性阻塞性肺疾病的疗效与安全性比较[J].中华结核和呼吸杂志,2006,29(6):363-367. 被引量：158
5Calverly PM, Towse LJ, Lee A. The timing of dose and pattern of bronchodilator of tiotropium (TIO) in stable COPD [ J ]. Eur Respir,2000,16(31 ) :56 -62.
6O' Donnell D, Fluge T, Gerkn F, et al. Effects of tiotropium on lung hyperinflation, dyspnoea and exercise tolerance in COPD[ J]. Eur Re- spit J,2004,23(9) :832 -840.
7Vincken W, Noord JA, Gressthorst AP, et al. Improved health out- comes in patients with COPD during one year treatment with tiotropium [ J]. Eur Respir,2002 ,19 :20.

二级参考文献25

1刘升明,王小平,王大礼,周玉民,吕嘉春,郑劲平,钟南山,冉丕鑫.广东部分地区慢性阻塞性肺疾病发病状况调查[J].中华医学杂志,2005,85(11):747-752. 被引量：150
2王秋月,张鸿,王笑秋,康健,于润江.噻托溴铵治疗慢性阻塞性肺疾病随机双盲双模拟对照临床试验[J].中国临床药理学杂志,2005,21(5):328-331. 被引量：11
3有创-无创序贯机械通气多中心研究协作组.以肺部感染控制窗为切换点行有创与无创序贯机械通气治疗慢性阻塞性肺疾病所致严重呼吸衰竭的随机对照研究[J].中华结核和呼吸杂志,2006,29(1):14-18. 被引量：279
4Barnes PJ,Stockley RA.COPD:current therapeutic interventions and future approaches.Eur Respir J,2005,25:1084-1106.
5Disse B,Reichl R,Speck G,et al.Ba 679 BR,a novel long-acting anticholinergic bronchodilator.Life Sci,1993,52:537-544.
6Takahashi T,Belvisi MG,Patel H,et al.Effect of Ba 679 BR,a novel long-acting anticholinergic agent,on cholinergic neurotransmission in guinea pig and human airways.Am J Respir Crit Care Med,1994,150(6 Pt 1):1640-1645.
72003 Update:Workshop Report,Global Strategy for Diagnosis,Management,and Prevention of COPD.National Heart,Lung,and Blood Institute and World Health Organization,Global initiative for chronic obstructive lung disease (GOLD).Available from:http://www.goldeopd.org/
8Casaburi R,Mahler DA,Jones PW,et al.A long-term evaluation of once-daily inhaled tiotropium in chronic obstructive pulmonary disease.Eur Respir J,2002,19:217-224.
9Littner MR,Ilowite JS,Tashkin DP,et al.Long-acting bronchodilation with once-daily dosing of tiotropium (Spiriva) in stable chronic obstructive pulmonary disease.Am J Respir Crit Care Med,2000,161 (4 Pt 1):1136-1142.
10Casaburi R,Briggs DD Jr,Donohue JF,et al.The spirometric efficacy of once-daily dosing with tiotropium in stable COPD:a 13-week multicenter trial.The US Tiotropium Study Group.Chest,2000,118:1294-1302.