鸡传染性鼻炎二价油乳剂灭活疫苗的近期免疫效力检验

Tests of Efficacy of Bivalent Inactivated Oil Adjuvant Vaccine to Avian Infectious Coryza

应用 3批鸡传染性鼻炎二价油乳剂灭活疫苗进行了安全性和近期免疫效力检验 ,安全性试验采用 15只鸡进行 ,胸肌注射疫苗 4～ 5mL/只后 ,逐日观察 ,结果鸡只食欲、精神未见异常 ,2周后观察 ,注射部位未发现明显异常和病变。用该疫苗免疫 (0 5mL/只 )后的鸡只对A型高致病力菌株的攻击保护率可达 10 0 % ,对C型高致病力菌株的攻击保护率为 93 3%。采用B

Three batches of bivalent inactivated oil adjuvant vaccine to avian infectious coryza were produced and the safety and efficacy of them were also evaluated in this study.15 chickens were injected intramuscularly with 4-5 mL vaccine,there was no significant sign to be observed,and no lesions on the injecting spot after 2 weeks.The vaccine could achieve a protective rate about 100% against challenge of high virulent strain of serovar A(Hp8)and 93 3% against challenge of serovar C(H18).The antibodies were also tested in this study by and SPA,and the results showed that the vaccine could stimulate high levels of antibody to Hpg.All the results demonstrated the good safty and efficacy of the vaccine,and it could play a big role in the prevention of infectious coryza in China.