根除幽门螺杆菌对儿童腹型过敏性紫癜疗效的研究

The effect of Helicobacter pylori eradication on henoch- schonlein purpura in children

目的探讨根除幽门螺杆菌(H.pylori)对儿童腹型过敏性紫癜(HSP)的临床疗效。方法选择130例已确诊为腹型HSP住院患儿,采用13C-UBT进行H.pylori检测,阳性者85例,分为治疗组45例和对照组40例。对照组给予常规治疗方案,治疗组在此基础上加用根除H.pylori三联治疗,比较其疗效及复发率。结果治疗组有效率为95.6%,对照组有效率为72.5%,2组比较差异有统计学意义(P<0.05);治疗组胃肠道症状缓解迅速,复发率为8.9%,而对照组为30%,2组差异有统计学意义(P<0.05)。结论 H.pylori感染与儿童腹型HSP密切相关,对于H.pylori阳性者给予根除H.pylori治疗,可有效提高疗效,降低复发率。

Objective To investigate the effect of Helicobacter pylori （ H. pylori） eradication on Henoch - Schonlein purpura （HSP）. Methods H. pylori was measured by 13C - UBT in 130 inpatients diagnosed as gastrointestinal HSP. Positive results were ob- tained in 85patients, who were then divided into treatment group （n = 45） and control group （n = 40）. The patients in control group were treated with conventional therapy while the patients in treatment group were treated with conventional therapy plus H. pylori eradication. The curative effect and recurrence rate of patients in the two groups were compared. Results The clinical effect of the treatment group was superior to that of the control group （ 95.6% vs. 72.5% ,P 〈 0.05 ）. The relapse rate of the treatment group was lower than that in the control group （8.9% vs. 30% ,P 〈 0.05）. Both the curative effect and recurrence rate were significantly different between the two groups （P 〈 0.05 ）. Conclusion H. pylori infection is correlated with the prognosis of gastrointestinal HSP. H. pylori eradication therapy is helpful to alleviate the gastrointestinal symptoms, improve the curative effect and reduce the recurrent rate.