免疫比浊法测定体检人群胃蛋白酶原水平与年龄和性别的关系

The Relationship Between Pepsinogen Level Distribution and Age and Gender in the Physical Examination People

目的分析健康体检人群的血清PG I、PGⅡ水平及PG I/II比值（PGR）与年龄和性别关系,并与胃镜检查结果比较及对验证PGI、PGII与PGR参考区间。方法采用免疫比浊法检测377名血清PG I和PGII水平并胃镜检查,分析影响PG水平的相关因素。结果消化性溃疡组血清PGI及PGII显著升高,PGR显著降低;萎缩性胃炎PGI显著降低,PGII升高,PGR显著降低。体检人群血清PGI和PGII水平男性高于总体水平;在18~75岁年龄段,随年龄增长,PGI和PGⅡ水平上升,PGI/PGⅡ比水平下降。结论健康体检人群中,消化性溃疡组血清PGI及PGII水平显著升高,PGR降低;萎缩性胃炎组PGI显著降低,PGII升高,PGR显著降低。血清PG水平与年龄、性别相关;联合测定血清PGⅠ、PGⅡ和PGR在健康人群胃部疾病筛查有重要意义。

Objective To explore the relations of the serum PGI, PC II levels and PC I/II ratio （PGR） with age and gender in the physical examination people and to verify the serum PGI, PGII and PGR reference range. Methods 377 cases were enrolled for physical examination and gastroscopy. The serum PC I and PGII levels were assayed by the immune turbidmetric method. The effects of age and gender on serum PG levels were ana- lyzed. Results The serum levels of PGI and PGII in peptic ulcer patients were obviously higher than that the av- erage levels, and the PGR in peptic ulcer patients were obviously lower. The PC I levels and PGR in gastritis trophic patients were significantly lower, but PGII were higher than that the average levels. The PGI and PGII levels of male were significantly higher than that average level. At age of 18 - 75, the serum PGI and PG H lev- els increased as age growth, but PGI/PG I[ ratio was decreased. The serum levels of PGI and PGII in peptic ulcer patients were obviously higher than that the average, but PGR obviously lower. The PG I levels and PGR in gastritis trophic patients were significantly lower, but PGII levels were higher than that the average. Conclu- sion The combined detection of serum PGI, PG II levels and PG I/II ratio have important clinical significance to stomach disease screening in physical examination.