摘要
在乙醇-水溶液中对灯盏花乙素进行酸水解制备野黄芩素,用正交试验对水解工艺进行优化.得到最佳水解条件:温度80℃,硫酸浓度20%(质量分数),乙醇浓度80%(体积分数),固液比1∶2(质量-体积比,mg/mL),反应时间3.5 h,该条件下的平均收率为90.7%.利用紫外光谱和核磁共振氢谱对其结构进行了表征.
Scutellarein is prepared by acidic hydrolysis of scutellarin, and the reaction conditions are optimized through orthogonal experiments. The optimal conditions for scutellarein hydrolysis are as follows： the temperature being 80℃, the concentration of aqueous sulfuric acid being 20% （Mass fraction）, the concentration of aqueous ethanol being 20% （Volume fraction）, the ratio of solid material weight to solvent volume was 1：2 （Solid -liq- uid ratio,mg/mL） and the reaction time being 3.5 hours. The mean yield of scutellarein is 90.08% under the optimal reaction conditions. The title compound is characterized by UV and 1H- NMR spectroscopic analyses.
出处
《昆明理工大学学报（自然科学版）》
CAS
北大核心
2013年第6期102-106,共5页
Journal of Kunming University of Science and Technology(Natural Science)
基金
国家自然科学基金(21062009)
云南省应用基础研究基金(2009ZC045M
2011FZ059)
云南省教育厅基金(2012Y533)
关键词
灯盏花乙素
野黄芩素
酸水解
正交试验
Scutellarin
Scutellarein
acidic hydrolysis
orthogonal experiment
