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胃肠道间质瘤的分子靶向治疗 被引量：1

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摘要 胃肠道间质瘤（GIST）主要由突变的c-kit或血小板源性生长因子受体α（PDGFRα）基因驱动.分子靶向药物伊马替尼（imatinib）的问世,成为了GIST患者分子靶向治疗里程碑式的进展.但伊马替尼根据GIST的基因型不同,而显示出不同活性,且KIT和PDGFRα突变状态和其突变外显子的类型与GIST对酪氨酸激酶抑制剂的临床反应相关.因此需要对不同突变类型的GIST患者进行突变类型检测,并分别选择相应的酪氨酸激酶抑制剂治疗.尽管酪氨酸激酶抑制剂在很大程度上改善了GIST患者的生存状态,但大约有20%的GIST原发对imatinib耐药,且多数患者在酪氨酸酶抑制剂治疗2年内形成继发耐药,因此将来GIST的治疗可能更加倾向于多种药物、多类药物,靶向多层面的胞内信号转导通路的联合使用.
作者 童仕伦 郑勇斌
机构地区 武汉大学人民医院胃肠外科
出处 《腹部外科》 2013年第6期371-373,共3页 Journal of Abdominal Surgery
关键词 胃肠道间质瘤 分子靶向治疗
分类号 R734.2 [医药卫生—肿瘤]
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  • 1贺慧颖,方伟岗,钟镐镐,李燕,郑杰,杜娟,衡万杰,吴秉铨.165例胃肠道间质瘤中c-kit和PDGFRA基因突变的检测和临床诊断意义[J].中华病理学杂志,2006,35(5):262-266. 被引量：73
  • 2Li J,Gong FJ,Shen L,et al.Post-operative imatinib in patients with intermediate or high risk gastrointestinal stromal tumour[J].Euro J Sur Oncol,2011,37(4):319-324.
  • 3Corless CL,Ballman KV,Antonescu C,et al.Relation of tumor pathologic and molecular features to outcome after surgical resection of localized primary gastrointestinal stromal tumor (GIST):Results of the intergroup phase Ⅲ trial ACOSOG Z9001[J].J Clin Oncol,2010,28 (15 Suppl):a10006.
  • 4Joensuu H,Eriksson M,Hartmann J,et al.Twelve vs 36 months of adjuvant imatinib as treatment of operable GIST with a high risk of recurrence:final results of a randomized trial (SSGXⅧ/AIO)[J].J Clin Oncol,2011,29(Suppl):aLBAI.
  • 5DeMatteo RP,Owzar K,Antonescu CR,et al.Efficacy of adjuvant imatinib mesylate following complete resection of localized,primary gastrointestinal stromal tumor (GIST) at high risk of recurrence:The U.S.Intergroup phase Ⅱ trial ACOSOG Z9000[C/OL].2011[2011-07-29].http://www.anco.org/ascov2/Meetings/Abstracts? &vmview = abst-detail-view&confID =53&abstractID = 10450.
  • 6Demetri GD,von Meherm M,Blanke CD,et al.Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors[J].N Engl J Med,2002,347(7):472-480.
  • 7Zalcberg JR,Verweij J,Casali PG,et al.Outcome of patients with advanced gastrointestinal stromal tumours croasing over to a daily imatinib dose of 800 mg after progression on 400 mg[J].Eur J Cancer,2005,41 (12):1751-1757.
  • 8Rios M,Lecesne A,Bui B,et al.Interruption of imatinib (IM)in GIST patients with advanced disease after one year of treatment:Updated results of the prospective French Sarcoma Group randomized phase Ⅲ trial on long term survival[J].J Clin Oncol,2007,25(18 Suppl):10016.
  • 9Raut CP,Posner M,Dessi J,et al,Surgical management of advanced gastrointestinal stromal tumors after treatment with targeted systemic therapy using kinase inhibitors[J].J Clin Oncol,2006,24(15):2325-2331.
  • 10DeMatteo RP,Maki RG,Singer S,et al.Results of tyrosine kinase inhibitor therapy followed by surgical resection for metastatic gastrointestinal stromal tumor[J].Ann Surg,2007,245 (3):347-352.

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  • 1Rubin BP, Heinrich MC, Corless CL. Gastrointestinal stromal tumour. Lancet, 2007,369 : 1731-1741.
  • 2Choi H. Response evaluation of gastrointestinal stromal tumor. Oncologist, 2008,13 ( Suppl 2) : 4-7.
  • 3Gao J, Dang Y, Sun N, et al. C-KIT mutations were closely as- sociated with the response to Imatinib in Chinese advanced gas- trointestinal stromal tumor patient. Med Oncol. , 2012,29 .. 3039- 3045.
  • 4Mazur MT, Clark HB. Gastric stromal tumors.. Reappraisal of histogenesis. Am J Surg Pathol, 1983,7: 507-519.
  • 5Hirota S, Isozaki K, Moriyama Y, et al. Gain-of-function muta- tions of c-kit in human gastrointestinal stromal tumors. Science, 1998,279 : 577-580.
  • 6Joensuu H, Roberts S, Sarlomo-Rikala M, et al. Effect of the tyro-sine kinase inhibitor STI571 in a patient with metastatic gas- trointestinal stromal tumor. N Engl J Med, 2001, 344: 1052- 1056.
  • 7DeVita VT Jr, Rosenberg SA. Two hundred years of cancer re- search. N Engl J Med,2012,366..2207-2214.
  • 8Joensuu H. Sunitinib for imatinib-resistant GIST. Lancet,2006, 368 : 1303-1304.
  • 9党运芝,高静,李健,李艳艳,田野,孙志伟,何琼,沈琳.胃肠间质瘤临床病理特征与基因分型(附660例分析)[J].中国实用外科杂志,2013,33(1):61-65. 被引量：29
  • 10徐佳,曹晖.胃肠间质瘤靶向治疗耐药的分子机制及治疗策略[J].中华胃肠外科杂志,2013,16(3):288-291. 被引量：4

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腹部外科
2013年 第6期

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