4Shimokawa H,Hiramori K,linuma H,et al.Anti-anginal effect of Fasudil,a Rho-kinsse inhibitor,in patients with stable effort angina:A multicenter study[J].J Cardiovasc Pharmacol,2002,40(5):751-761.
5Fukumoto Y,Matoba T,Ito A,et al.Acute vasodilator effect of a Rho-kinase inhibitor,fasudil,in patients with severe pulmonary hypertension[J].Heart,2005,91:391-392.
6Ishikura K,Yamada N,Ito M,et al.Beneficial acute effects of Rho-kinase inhibitor in patients with pulmonary arterial hypertension[J].Circ J,2006,70(2):174-178.
7Masumoto A,Hirooka Y,Shimokawa H,et al.Possible involvement of Rho-kinase in the pathogenesis of hypertension in humans[J].Hypertension,2001,38(6):1307-1310.
8Kishi T,Hirooka Y,Masumoto A,et al.Rho-kinase inhibitor improves increased vascular resistance and impaired vasodilation of the forearm in patients with heart failure[J].Circulation,2005,111:2741-2747.
9Uehata M,Ishizaki T,Satoh H,et al.Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension[J].Nature,1997,389:990-994.
10Somlyo AP,Somlyo AV.Ca^2+ sensitivity of smooth muscle and non-muscle myosin Ⅱ:Modulated by G proteins,kinases,and myosin phosphatase[J].Physiol Rev,2003,83:1325-1358.
