2010-2012年关节感染208株病原菌分布及耐药监测

Distribution and drug resistance of 208 strains of pathogens in joint infection during 2010 and 2012

目的了解关节感染忠者细菌分布及耐药情况。方法收集2010—2012年本院临床分离的关节感染病原菌208株,药敏试验采用K-B法和E-TEST法。结果占关节感染比例最高病原菌为凝固酶阴性葡萄球菌(42.3%),所占比例呈逐年年升高趋势;凝固酶阴性葡萄球菌对氨苄西林-舒巴坦、头孢呋辛、青霉素、头他唑啉和红霉素有较高耐药率;而对复方磺胺甲恶唑、左旋氧氟沙星、磷霉素、庆荡霉素、克林霉素和利福平耐药率,3年间有不同程度的增加;对力奈唑烷和万古霉素敏感率为100%。结论关节感染主要病原菌为凝固酶阴性葡萄球菌,耐药率有逐年增多趋势。

Objective To determine the distribution and drug resistance of pathogens in joint infection. Methods A total of 208 strains of pathogens in joint infection were studied during the year of 2010 through 2012. K-B and E-TEST method were used in drug susceptibility test. Results Coagulase-negative staphylococci accounted for the most percentage （42.3%） in all the patho- gens in joint infection and increased annually. The resistance rates of coagulase-negative staphylococci to Ampicillin/Sulbactam, Cefuroxime, Levofloxacin, Penicillin, Erythromycin and Cephazoline were high, and it increased to Trimethoprim-Sulfamethox- azole, Levofloxacin, Fosfomycin, Gentamicin, Clindamycin and Rifampicin in the three years. The sensitivities of coagulase-nega- tive staphylococci to Vancomycin and Linezolid were 100%. Conclusion Coagulase-negative staphylococci are the predominant organisms in joint infection and their resistance rates to antibiotic drugs increase year by year.