复方甘草酸苷联合窄谱中波紫外线治疗斑秃的疗效观察

Observation of the Curative Effect of the Treatment of Alopecia Areata with Compound Glycyrrhizin Combined with NB-UVB

目的:评价复方甘草酸苷联合窄谱中波紫外线(NB-UVB)治疗斑秃的临床疗效及安全性。方法:115名斑秃患者随机分为试验组58例和对照组57例。两组均给予NB-UVB照射治疗,每周2次,地万溶液外涂,bid,共治疗12周。试验组在此基础上给予复方甘草酸苷胶囊50 mg,po tid,连续12周。治疗后比较两组疗效及不良反应,并于3个月后随访。结果:试验组总有效率86.21%,对照组总有效率64.91%,差异有统计学意义(P<0.05)。试验组发生1例不良反应,对照组发生2例。治疗后3个月随访,试验组复发2例,对照组复发5例。两组复发率差异有统计学意义(P<0.05)。结论:复方甘草酸苷联合窄谱中波紫外线治疗斑秃不良反应少,具有疗效、安全性和耐受性好等优点,值得临床推广。

Objective：：To evaluate the efficacy and safety of alopecia areata treated with compound glycyrrhizin and narrow band ultraviolet B（NB-UVB）.Methods：115 patients were randomly divided into the treatment group with 58 cases and the controlled group with 57 cases.Both groups were treated with NB-UVB twice a week and embrocated diwan solution twice a day;on the basis of the controlled group,the treatment group were treated with compound glycyrrhizin, 50mg each time,three times a day.Their curative effect and adverse reactions were evaluated for 12 weeks after the treatment.Results：The total effectiveness of the treatment group was 86.21%and that of the controlled group were 64.91%. There was statistically significant difference（P0.05）for the two groups.Three months later,recurrence in 2 cases（3.45%）of the treatment group and the control group recurrence in 5 cases（8.78%）,there was statisticaily significant differences（P0.05）.Conclusion：The compound glycyrrhizin combined with NB-UVB was an effective,tolerable and safe method with few adverse reactions to treat alopecia areata;therefore,its clinical promotion was worth while.