血清CA125与CA153联合检测对子宫内膜癌的诊断价值

Evaluation of serum carbohydrate antigen 125 and 153 joint detection in diagnosis and prevention of endometrial cancer

目的探讨血清CA125、CA153联合检测对子宫内膜癌诊断、预防的临床价值。方法采用发光免疫分析法对47例子宫内膜癌患者、51例子宫肌瘤患者进行血清CA125、CA153检测,分析两者单独及联合检测对子宫内膜癌诊断的价值。结果治疗前研究组CA125和CA153水平均显著高于对照组(P<0.05);治疗后研究组CA125和CA153水平显著下降,与治疗前相比,差异具有统计学意义(P<0.05),其中治疗后研究组与对照组差异无统计学意义(P>0.05)。无残留癌灶组CA125和CA153水平均明显低于有残留癌灶组(t=2.462,2.786,P<0.05)。与单项检测相比,联合检测虽然特异性有所降低(χ2=3.372,P>0.05),但灵敏度和准确性显著提高(χ2=46.341、52.253,P<0.05)。结论 CA125和CA153联合检测对鉴别子宫良、恶性疾病和判断预后及复发有重要意义。

Objective To explore the clinical value of serum CA125 and CA153 joint detection for endometrial cancer diagnosis and prevention. Methods Chemiluminescence immunoassay was used to detect serum levels of HE4 and CA125 in 47 cases of endo- metrial carcinoma and 51 cases of uterine fibroids patients. The results were analyzed statistically. Results Before treatment,the levels of CA125 and CA153 in study group were significantly higher than those in control group（P〈0.05）. The levles of CA125 and CA153 in study group significantly decreased（P〈0.05）, which were close to control group（P〉0.05）. The levels of CA125 and CA153 in patients without tumor residual were significantly lower than those in patients with tumor residual（t= 2. 462,2. 786, P〈0.05）. Compared with single index detection, the sensitivity and the accuracy of joint detection improved significantly（x^2 = 46. 341,52. 253,P〈0.05）. Conclusion Combined detection of CA125 and CA153 has important value in differential diagnosis of benign and malignant uterine diseases.