临床感染病原菌结构和耐药水平的变化

Changes in bacterial pathogen and their resistance in clinical infection

目的 研究该院临床感染病原菌结构的变化以及主要病原菌耐药水平的变化.方法 分析2000年至2012年该院临床标本细菌鉴定及药敏试验结果.结果 金黄色葡萄球菌构成比大幅度下降、铜绿假单胞菌构成比无明显变化,鲍曼不动杆菌构成比明显上升.铜绿假单胞菌和鲍曼不动杆菌对亚胺培南的耐药率逐渐升高.金黄色葡萄球菌对苯唑西林的耐药率2003后在60%～70%之间波动.结论 13年来该院感染病原菌的结构发生了明显变化,主要病原菌的耐药水平也是达到了非常高的水平,提示临床抗感染重点需要做相应调整.

Objective To investigate the change in bacterial isolate and the resistance of most common pathogenic bacteria in a hospital. Methods To analyze the data of bacterial isolates and bacterial resistance from 2000 to 2012. Results The constituent ra tio of Staphylococcus aureus （ SAU ） , Pseudomonas aeruginosa （PAE） and Acinetobacter baumannii （ABA） were decreased d ramatic- ally,slightly fluctuated and increased obviously, respectively. The resistant rates of ABA and PAE to lmipenem were increased and resistant rate of SAU to oxacillin ranged between 60% and 70% from 2003 to 2012. Conclusion The obviously changes in constitu- ent ratio of pathogen in the hospital were observed in the past thirteen years, and the three most frequently isolated pathogens showed high level resistance to the key antibiotics. The results suggest that clinical anti-infectlon strategies should be adjustment properly.