3种血清化学指标检测对冠状动脉硬化性心脏病的应用价值

Application valure of 3 kinds of serum indexs in coronary atherosclerosis heart disease patients

目的探讨3种血清化学指标检测对冠状动脉硬化性心脏病(CHD)的应用价值。方法在日立7180全自动生化分析仪上检测实验组和正常组的血清样本中Lp(a)、缺血修饰清蛋白(IMA)和同型半胱氨酸(Hcy)的水平,并对其检测结果进行分析比较。结果实验组血清样本中Lp(a)、IMA和Hcy的浓度明显高于正常组,两者比较差异有统计学意义(P<0.05);实验组血清Lp(a)、IMA和Hcy单项检测,阳性检出率分别为47.2%、58.5%、43.4%,3项联合检测阳性检出率高达79.2%;正常组血清Lp(a)、IMA和Hcy单项检测,阳性检出率分别为2%、0%、0%,3项联合检测阳性检出率仅为2.0%。联合检测阳性检出率与单项检测阳性检出率比较差异有统计学意义(P<0.05)。结论联合检测血清Lp(a)、IMA和Hcy的水平可作为诊断CHD临床常规预测指标,有助于提高CHD疾病的阳性检出率,其浓度水平变化能为CHD的临床诊断、病情监测和预后方面提供一定参考依据。

Objective To analyse the coronary atherosclerosis heart disease patients serum Lp（a） ,IMA,and Hcy levels. Methods Detection of serum samples of experimental group and normal group in the Lp（a）, IMA and H cy levels on the Hitachi 7180, and the test results were analyzed and compared. Results The experimental group in serum samples of Lp（a）, IMA and Hcy was sig- nificantly higher than that in normal group, there was statistically significant or highly significant difference between them（P〈 0.05） lserum Lp（a） ,IMA and Hcy single detection,the positive rates were 47.2% ,58.5% ,43.4% ,the combined detection of three positive detection rate as high as 79.2%;normal serum Lp（a） ,IMA and Hcy single detection,the positive rates were 2% ,0% ,0%, three combined detection the positive detection rate was only 2 %. The combined detection of single detection positive rate and posi- tive rate,the difference was statistically significant（P〈0.05）. Conclusion The combined detection of serum Lp（a） ,IMA and Hcy can be used as the level of diagnosis of CHD in routine clinical predictors , help to improve the positive rate of CHD diseases,its con- centration level changes can provide certain reference for the clinical diagnosis,disease monitoring and prognosis of CHD.