127株阴沟肠杆菌耐药性监测分析

Analysis of drug resistance of 127 Enterobactter cloacae isolated strains

目的了解该院临床分离的阴沟肠杆菌的分布与耐药性的特点,以便更好地指导临床用药。方法用VITEK-2COMPACT全自动分析系统(法国生物梅里埃公司)进行菌株鉴定和药敏试验。结果 127株阴沟肠杆菌主要来源于伤口分泌物(47.24%)、痰液(34.65%)、中段尿(6.30%),药敏结果显示阴沟肠杆菌对氨苄西林、氨苄西林/舒巴坦、呋喃妥因、头孢替坦、头孢唑啉的耐药率均高达90%以上,对亚胺培南耐药率仅为1.57%,显示出高敏感性。结论阴沟肠杆菌耐药性增加,出现了对碳青霉烯类抗菌药物不敏感菌株,建议临床应根据药物敏感试验结果合理使用抗菌药物,减少耐药菌株的产生。

Objective To investigate the characteristics of distribution and antimicrobial resistance of Enterobacter cloacae iso- lates in the hospital, so as to guide clinical treatment. Methods VITEK-2 COMPACT automatic analysis system was uesed for strain identification and drug sensitive test. Results 127 strains of Enterobacter cloacae were isolated mainly from wound secretion （47.24 % ）, sputum（34.65 %）, and urine（6.30 %）. The results of drug sensitivity showed Enterobacter cloacae had high resistance to ampicillin,ampicillin/sulbactam,nitrofurantin, and zygosaccharomyces cefotetan, and the rates of drug resistance were all higher than 90%. However,Enterobaeter cloacae showed high sensibility to imipenem with the resistant rate only 1.57%. Conclusion In- creasing drug resistance of Enterobacter cloacae and the emergence of the carbapenem antibiotics resistant strain suggest that rec- ommendations for clinical rational use of antibiotics should be based on the results of drug sensitive test.