男性急性冠脉综合征患者血清睾酮与炎性因子改变的相关性（英文）

Correlation between serum testosterone level and changes of levels of inflammatory factors in male patients with acute coronary syndrome

目的：测定不同类型冠心病（CHD）患者血清睾酮、血浆白介素-18（IL-18）、IL-10的水平，探讨睾酮与IL-18、IL-10的相关性，及在CHD发生发展中的可能作用。方法：96例男性CHD患者被分为急性心梗（AMI）组（35例）、不稳定型心绞痛（UAP）组（32例）和稳定型心绞痛（SAP）组（29例），另选择30例经冠脉造影排除冠心病的患者为非冠心病对照组，采用酶联免疫吸附法测定各组血清睾酮，血浆IL-18、IL-10水平。结果：血清睾酮水平在UAP组、AMI组均显著低于非冠心病对照组[（6．89±1．35）mmol／L比（5．02±1．87）mmol／L比（13．46±1．99）mmol／L，t=1．917～2．365，P均〈0．05]，且AMI组显著低于UAP组（t=1．034，P〈0．05）；IL-18水平在SAP组、UAP组和AMI组均显著高于非冠心病对照组[（209．32±80．49）pg／ml比（316．78±75．63）pg／ml比（457．78±83．21）pg／ml比（146．72±79．36）pg／ml，t=2．016～3．167，P均〈0．05]，且UAP、AMI组显著高于SAP组（t=2．173，2．596，P〈0．05）；IL-10水平在SAP组、UAP组和AMI组显著高于非冠心病对照组[（116．45±42．76）pg／ml比（85．64±27．33）pg／ml比（70．26±18．55）pg／ml比（48．46±18．27）pg／ml，t=2．9972．018，P均d0．053，而AMI组、UAP组显著低于SAP组（t-2．034，2．291，P〈0．05）。Pearson直线回归分析显示，CHD组的血清睾酮水平与IL．10（r=-0．678，P〈0．01），IL-18（r=-0．579，P〈O．01）水平呈显著负相关。结论：冠心病血清睾酮及IL-18，IL-10水平有显著改变，且血清睾酮与IL-18，IL-10呈显著负相关，可作为评价冠状动脉粥样硬化病变的新指标。

Objective： To measure serum testosterone level, plasma levels of interleukin-18 （IL-18） and IL-10 and explore their correlation in patients with different types of coronary heart disease （CHD）, and their possible role in occurrence and development of CHD. Methods： A total of 96 male CHD patients were divided into acute myocardial infarction （AMI） group （n=35）, unstable angina pectoris （UAP） group （n=32） and stable angina pectoris （SAP） group （n= 29）. Another 30 patients who were excluded for CHD by coronary angiography were enrolled as non CHD control group. Enzyme linked immunosorbent assay （ELISA） was used to measure serum testosterone level and plasma levels of IL-18 and IL-10 in all groups. Results： Compared with non CHD control group, there were significant decreases in serum testosterone level F （13.46± 1.99） mmol/L vs. （6.89±1.35） mmol/L vs. （5.02± 1.87） mmol/L, t = 1. 917±2. 365, P〈0.05 both] in UAP group and AMI group, and that of AMI group was significantly lower than that of UAP group, t = 1. 034, P〈0.05 ; there were significant increases in IL-18 levels [ （146.72 ± 79.36） pg/mlvs. （209.32±80.49） pg/mlvs. （316.78±75.63） pg/mlvs. （457.78±83.21） pg/ml, t=2.016- 3. 167, P〈0.05 all] in SAP group, UAP group and AMI group, and those of UAP group and AMI group were significantly higher than that of SAP group, t = 2. 173, 2. 596, P（0.05; there were significant increases in IL-10 levels [ （48. 46±18.27） pg/ml vs. （116.45±42.76） pg/ml vs. （85.64±27.33） pg/ml vs. （70.26±18.55） pg/ml, t= 2. 997-2. 018, P〈0.05 all] in SAP group, UAP group and AMI group, and those of AMI group and UAP group were significantly lower than that of SAP group （t = 2. 034, 2. 291, P〈0.05 both）. Pearson linear regression analysis indicated that serum testosterone level was negatively correlated with levels of IL-10 （ r = - 0. 678, P〈 0.01） and IL-18 （r=-0. 579, P〈0.01） in CHD group. Conclusion： There are significant changes in serum testosterone level and plasma IL-18, IL-10 levels, and testosterone level is significantly negatively related with IL-18, IL-10 levels, and they can be regard as new indexes assessing coronary atherosclerotic lesion.