HPV在宫颈炎、宫颈癌前病变、宫颈癌中的检测及意义分析

Detection and Clinical Value of HPV in Cervicitis,Cervical Precancerous Lesions and Carcinoma

目的研究人乳头瘤病毒(HPV)在宫颈炎、宫颈癌前病变、宫颈癌中的水平及临床意义。方法随机抽取2009年8月至2012年10月在广州医学院附属深圳沙井医院妇科就诊的宫颈炎、宫颈癌前病变、宫颈癌患者各50例,检测HPV阳性例数、HPV水平及HPV阳性患者中HPV DNA亚型的构成情况。结果 150例患者中,HPV感染98例,阳性率为63.33%,宫颈炎、宫颈癌前病变、宫颈癌的HPV感染率分别为22%(11/50)、78%(39/50)、96%(48/50);HPV水平呈现宫颈炎组<宫颈癌前病变组<宫颈癌组(P<0.05);HPV-DNA-16、HPV-DNA-18阳性率最高,分别为89.80%、86.73%;HPV-DNA-52、HPV-DNA-56、HPV-DNA-58阳性率其次,分别为52.04%、57.14%、50%。三组HPV-DNA各亚型的阳性率呈现宫颈炎组<宫颈癌前病变组<宫颈癌组(P<0.05)。结论高危型HPV-DNA类型检测有助于宫颈癌的早期诊断,具有重要的临床价值。

Objective To study the content and clinical value of human papulloma virus（ HPV） in cervicitis,cervical precancerous lesions and carcinoma. Methods Randomly selected from Aug. 2009 to Oct. 2012 in Guangzhou Medical University Affiliated Shenzhen Shajing Hospital Gynecological Department,50 cases each of cervicitis,cervical precancerous lesions,and cervical cancer were included in the study,HPVpositive cases,HPV level and HPV-positive patients DNA subtype composition were tested. Results In 150 patients,there were 98 cases of HPV infection,the positive rate was 63. 33%,cervicitis,cervical precancerous lesions,carcinoma of the cervix infection rates were 22%（ 11/50）,78%（ 39/50）,96%（ 48/50）. HPV level showed chronic cervicitis group cervical precancerous lesion group cervical cancer group. The positive rate of HPV-DNA-16 and HPV-DNA-18 were highest which were 89. 80% and 86. 73%,positive rate of HPV-DNA-52,HPV-DNA-56,HPV-DNA-58 were secondly which were 52. 04%,57. 14%,50% and showed chronic cervicitis group cervical precancerous lesion group cervical cancer group（ P 0. 05）. Conclusion Detection of high-risk HPV DNA types has positive clinical value for it is helpful for early diagnosis of cervical cancer.