氟比洛芬酯复合丙泊酚应用于胃肠外科手术镇痛的临床研究

Clinical Study of Flurbiprofen Combined with Propofol for Analgesia in Gastrointestinal Surgery

目的观察氟比洛芬酯复合丙泊酚用于胃肠手术的镇痛效果。方法选择2011年3月至2013年7月在滨州医学院烟台附属医院就诊的120例胃肠外科手术患者,按照随机数字表法分为氟比洛芬酯＋丙泊酚组和丙泊酚组。患者均给予2 mg/kg丙泊酚＋0.2 mg/kg阿曲库铵＋2~4μg/kg芬太尼麻醉诱导。氟比洛芬酯＋丙泊酚组患者给予氟比洛芬酯2 mg/mL＋生理盐水100 mL进行术后镇痛,丙泊酚组患者单纯给予100 mL生理盐水进行术后镇痛。术后对两组患者不同时段的VAS及Ramsay评分进行比较,并记录术后患者体征以及不良反应。结果术后VAS以及Ramsay评分氟比洛芬酯＋丙泊酚组均显著低于丙泊酚组（P〈0.05）;而两组患者的手术出血量、心率、血压及血氧饱和度比较均无统计学意义（P〉0.05）;术后氟比洛芬酯＋丙泊酚组患者恶心、呕吐、嗜睡、头痛、呼吸抑制以及皮疹的发生率低于丙泊酚组（P〈0.05）。结论氟比洛芬酯复合丙泊酚用于胃肠手术的术中及术后镇痛疗效肯定,不良反应少,值得临床推广应用。

Objective To observe the analgesic effect of flurbiprofen combined with propofol in gastrointestinal surgery. Methods A total of 120 cases of gastrointestinal surgery patients during Mar. 2011 and Jul. 2013 from Yantai Affiliated Hospital of Binzhou Medical University were divided into two groups by random digits table,flurbiprofen ＋ propofol group and propofol group. All of the patients received 2 mg/kg propofol ＋ 0. 2 mg/kg atracurium ＋ 2-4 μg/kg fentanyl for anesthesia induction. 2 mg/mL flurbiprofen ＋ 100 mL normal saline were administered for flurbiprofen ＋ propofol group and 100 mL normal saline were administered for propofol group for postoperative analgesia. VAS and Ramsay scale,physical sign and adverse effects were recorded and compared. Results VAS and Ramsay score of flurbiprofen ＋ propofol group were significantly lower than propofol group（ P 0. 05）. There was no significant deviation in surgery bleeding volume,heart rate,blood pressure and saturation of blood oxygen（ P 0. 05）. Incidence of nausea,disgorging,drowsiness, cephalea,respiratory depression and erythra in flurbiprofen ＋ propofol group were significantly lower than propofol group（ P 0. 05）. Conclusion Analgesia effect of flurbiprofen combined with propofol in intraoperative and postoperative gastrointestinal surgery has affirmative effect and less side effects,which is worth for clinical generalization.