中草药消除细菌耐药性质粒研究进展

Progress on Antiplasmid Effect of Chinese Herbal Medicine

常见病原微生物对抗微生物药物的耐药性正逐渐增加,已引起国内外学者的广泛关注。目前研究者一致认为抗微生物药物的滥用及随之产生的选择性压力是许多耐药菌出现的最主要原因。而从基因基础考虑,耐药性的产生则主要与质粒有关,质粒作为染色体外的DNA序列能够将耐药基因传递给环境中的其他细菌,从而引起多重耐药菌的出现。细菌耐药质粒自发消失的几率很低,但一些中草药能够使该几率增加。论文就中草药的耐药质粒消除作用及其机理进行综述。

The increasing antimicrobial resistance of common pathogens has led to a growing concern both at home and abroad.The overuse of antimicrobials and consequent antimicrobial selection pressure are thought to be the most important factors contributing to the appearance of different kinds of resistant microbes.The genetical basis of resistance is often the plasmid,which can be transferred to other bacteria in the environment of the recipient,and these extrachromosomal DNA sequences can be responsible for the emergence of multiple resistance to antimicrobials.Plasmid may be lost spontaneously in a very low frequency,but certain effects,such as some Chinese herbal medicines,can increase the probability of plasmid loss.A brief review of literature on the antiplasmid effect and the mechanisms of some Chinese herbal medicines was made.