2-(取代苯氧基)-5-羟基嘧啶类化合物的制备方法研究

Synthesis of 2-substitudephenoxy-5-benzyloxypyrimidines compounds

目的探索2-取代苯氧基-5-苯甲氧基嘧啶、2-取代苯氧基-5-羟基嘧啶类化合物的制备方法。方法以2-氯-5-羟基嘧啶为起始原料,经溴苄羟基保护、威廉森醚合成法、脱苄基保护等多步反应制得目标化合物。结果采用该合成路线制得13个未见文献报道的取代苯氧基嘧啶类化合物。结论本研究提出了一条操作简便、条件温和的全新苯氧基嘧啶类化合物合成方法。

Objective To prepare 2-substitudephenoxy-5 - benzyloxypyrimidines and 2 - substitudephenoxy-5-hydroxypyrimi- dines which had not been reported. Methods The target compounds were prepared from 2-ehlorine-5-hydroxypyrimidine through hydroxy protection,Williamsom reaction and reduction of benzyl group. Results The synthetic process provided a simple, easy diposal procedure and high overall yield. Fourteen new phenoxy pyrimidines compounds were prepared. Conclusions It was a new synthetic method which was easy to operate with moderate reaction conditions.