度他雄胺纳米悬浮液的制备

Preparation of dutasteride nanometer suspension

目的运用高压均质技术制备度他雄胺纳米悬浮液。方法以粒径、多分散性和Zeta电位为考察指标,研究均质压力、循环次数、表面活性剂种类和浓度等因素对纳米悬浮液性质的影响,并考察度他雄胺的溶解度及药物溶出速率。结果均质压力是影响纳米粒径的主要因素。纳米尺度的度他雄胺的溶解度和体外溶出速率比原药明显提高。结论高压均质技术可以成功用于制备度他雄胺纳米悬浮液。

Objective To prepare dutasteride nanometer suspension by high pressure homogenization （HPH）. Methods Using particle size, polydispersity, and Zeta electric potential as the investigation indexes, research was made in the effects of homogenization pressure, cycle indexes, and the species and concentration of surfactants on the quality of nanometer suspension. Moreover, the solubility and dissolution velocity of dutasteride were investigated. Results Homogenization pressure was the key factor that influenced the nanoparticle size. Compared with the solubility and dissolution velocity of the crude drug powder, those of dutasteride with nanoparticle were significantly improved. Conclusion High pressure homogenization technique can be successfully used to prepare dutasteride nanometer suspension.