早期应用激素对PBSI患者生存及预后的改善作用分析

Improvement in survival and prognosis of patients with PBSI through early application of hormones

目的 探讨早期应用激素对原发性脑干损伤（PBSI）患者生存及预后改善的效果.方法 收集上海曙光医院2009年6月～2013年6月收治的PBSI患者100例,按收治的时间分为实验组与对照组,每组各50例.对照组给予常规治疗,实验组在确诊后即应用甲基强的松龙治疗.分别于住院后4～7 d监测两组的颅内压,对两组的格拉斯哥结果 评分（GOS）、格拉斯哥昏迷评分（GCS）、语言障碍程度和运动功能障碍的程度进行评分,并进行比较.结果 与对照组比较,实验组的神经功能恢复速度较快且恢复的程度更好,两组间的差异有统计学意义（P＜0.05或P＜0.01）.结论 早期应用甲基强的松龙治疗PBSI,对改善患者的生存率、抑制继发性损伤及改善患者的预后都有积极的意义.

Objective To explore the improvement in the survival and prognosis of patients with primary brain stem injury （PBSI） through early application of hormones. Methods 100 patients with PBSI who were hospitalized in Shanghai Shuguang Hospital between June 2009 and June 2012 were chosen and divided into experimental and control group with 50 cases in each group according to the time of hospitalization. The control group received the traditional treatment, while the experimental group received the treatment with medaron after final diagnosis. The intracranial pressure of both groups was monitored 4 to 7 days after the hospitalization. The GOS, GCS, the degree of language barrier, and motor dysfunction of the two groups were evaluated, and the results were compared. Results In the experimental group, the neurological function recovered faster and the degree of recovery was better than those in the control group. There were significant differences between the two groups. Conclusion Early application of medaron to the treatment of PBSI has a positive significance in improving the patients＂survival rate, inhibiting the secondary injury, and improving the prognosis.