不同他汀类治疗老年冠心病伴高胆固醇血症的疗效比较

Comparison of curative effects among different statin drugs on senile patients with coronary artery disease complicated with hypercholesterolemia

目的研究不同他汀类药物对老年冠心病伴高胆固醇血症患者的疗效和安全性。方法选取老年冠心病伴高胆固醇血症患者186例,随机分为3组,分别给予阿托伐他汀(20 mg/d)、辛伐他汀(20 mg/d)和瑞舒伐他汀(10 mg/d)治疗,疗程均为12 w。在治疗前后分别检测患者总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C),并记录不良反应。结果治疗后,3组TC、TG、LDL-C均有所改善(P<0.05),其中瑞舒伐他汀组较其他两组改善程度更为明显(P<0.05),而阿托伐他汀组与辛伐他汀组间改善程度无统计学差异(P>0.05)。3组不良反应发生率之间无统计学差异(P>0.05)。结论瑞舒伐他汀对老年冠心病伴高胆固醇血症患者疗效更好,且安全可靠。

Objective To study the curative effects and safety of different statin drugs on senile patients with coronary artery disease complicated with hypereholesterolemia. Methods 186 patients with coronary artery disease complicated with hypercholesterolemia were enrolled in this study and randomly divided into three groups which respectively received atorvastatin （20 mg/ d ） , simvastatin（ 20 mg/d） , and rosuvastatin（ 10 mg/d）for 12 weeks. Before and after the treatment, detection was made in patients＇TC, TG, LDL-C, and HDL-C, and also adverse reactions of the drugs were recorded. Results After the treatment, the TC, TG, and LDL-C of the three groups were improved （ P 〈 0.05 ）. Among the three groups, and the degree of improvement in rosuvastatin group was more significant than atorvastatin and simvastafin groups （ P 〈 0.05 ）, but there was no difference in the degree of improvement between atorvastatin and simvastatin groups （ P 〉 0.05）. There was no significant difference in the incidence of drug adverse reactions among the three groups （ P 〉 0.05）. Conclusion Rosuvastatin has better curative effect than atorvastatin and simvastatin on senile patients with coronary artery disease complicated with hypercholesterolemia, and itg a safe and reliable treatment.