摘要
很多心血管疾病患者在进行阿司匹林治疗时效果不佳,也就是产生所谓"阿司匹林抵抗"。通过生化方法测定,可以将阿司匹林抵抗分为三种不同类型,即药代动力学型、药效学型、假抵抗型。实验室检测通过活体评估血小板功能及来自活体的血小板聚集两种途径来评价阿司匹林对血小板的作用。研究发现产生阿司匹林抵抗的因素有很多,而目前的研究方向集中在对单核苷酸多态性的分析研究。
Many patients with cardiovascular disease still would happen cardiovascular disease during treatment with aspirin, which is called ＂aspirin resistance＂. By biochemical methods, we divided aspirin resistance into three different types, which are pharmacokinetics, pharmacodynamics, false resistance type. In laboratory, we evaluate the role of aspirin on platelet in two ways,test assessment ofplatelet function in vivo and platelet aggregation. Researchs found that there are many factors relative with the occurence of aspirin resistance, and the research direction of the current research focuse on the analysis of single nucleotide polymorphisms.
出处
《中国医药指南》
2013年第34期65-66,共2页
Guide of China Medicine
关键词
阿司匹林抵抗
检测方法
血小板聚集
基因多态性
Aspirin resistance
Detection method
Platelet aggregation
Gene polymorphism
