阿托品救治有机磷中毒不同给药途径的疗效比较

Study on Atropine Administration Methods in Rescuing Patients with Acute Organophosphorus Pesticide Poisoning

目的分析基层医院救治有机磷中毒患者时,阿托品不同给药方式的疗效差异,为探索其最佳给药方法提供依据。方法回顾分析75例急性有机磷农药中毒患者的临床资料,25例进行人工间歇静脉推注阿托品法(A组),25例采用微量泵持续静脉输注阿托品法(B组,25例先间歇静脉推注阿托品,达阿托品化后再用微量泵泵入阿托品(C组),分析比较三组阿托品化时间、用量、住院时间、疗效以及不良反应和并发症。结果 C组阿托品化时间、用量、住院时间、阿托品过量、不足中毒、用量、尿潴留和多器官功能损害等明显降低而治愈率显著提高(P<0.05)。结论采用阿托品人工静脉推注,待患者阿托品化再予以微量泵给药,不仅起效速度快,而且恒速恒量,不良反应少,疗效较好,值得临床推广使用。

Objective To explore the effects of different atropine medications in remedy of severely acute organophosphorus pesticide. MethOds A retrospective study were performed.This study was carried out in 75 patients with acute organophosphorus pesticide poisoning. The patients were divided into three groups according atropine medications： Group A（25 cases）, were treated with intravenous injection of atropine and artificial; Group B（25 cases）directly with micro pump delivery, Group C（25 cases）achieved using micro-pump after atropine administration patients are atropine artificial intravenous injection, the patient achieved using micro-pump after atropine administration; Compared the efficacy and complications among the three groups. Results There is significant difference between minim continuous pump after atropine administration and interval injecting or minim continuous pump. As a result, the patients in Group C were more effective and fewer complications than that in Group A and C. Conclusion Using micro-pump after atropine administration artificial intravenous injection of atropine was the better effect, it has proved to be a fine medication.