2型糖尿病患者中代谢综合征与动脉粥样硬化的相关性

Correlation between metabolic syndrome and carotid atherosclerosis in type 2 diabetes patients

目的分析2型糖尿病患者中代谢综合征（Ms）与动脉粥样硬化的相关性。方法选取2011年10月-2012年9月在江苏省海门市人民医院内分泌科住院治疗的2型糖尿病患者300例，所有患者均接受生化指标检测和颈动脉超声检查。结果300例2型糖尿病患者中，MS的发生率为82．7％（248／300），其中男性为76．5％（117／153），女性为89．1％（131／147）。与无MS的患者（非MS组）比较，MS患者（MS组）中女性构成比、年龄、体质指数、收缩压、舒张压、总胆固醇和三酰甘油水平均显著升高（P值分别〈0．01、O．05）。MS组中颈动脉粥样硬化斑块的检出率显著高于非MS组（P=0．0003）。Logistic回归分析结果显示，校正糖尿病家族史、糖尿病病程和糖化血红蛋白后，MS是颈动脉粥样硬化的危险因素（比数比-3．36，95％CI为1．02～11．13，P=0．047）。结论江苏海门地区住院治疗的2型糖尿病患者中，MS的发生率已达82．7％，且MS是动脉粥样硬化形成的独立危险因素。

Objective To assess the correlation between metabolic syndrome and atherosclerosis in patients with type 2 diabetes. Methods We performed a cross-sectional survey in 300 type 2 diabetes inpatients treated from October 2011 to September 2012. All the patients received measurements of biochemical markers and carotid ultrasonograph. Results The incidence of metabolic syndrome was 82.7% （248/300） in all 300 patients, 76.5% （117/153） in males and 89. 1% （131/147） in females. Compared with patients without metabolic syndrome, those with metabolic syndrome were elder, had higher proportion of females, higher body mass index （BMI）, higher systolic blood pressure （SBP）, higher diastolic blood pressure （DBP）, higher total cholesterol and triglycerides （P〈0.01 or 0.05）. Moreover, detection rate of carotid atherosclerotic plaque was significantly higher in patients with metabolic syndrome compared with those without metabolic syndrome （ P = 0. 000 3）. Logistic regression analysis showed that, after adjustments for conventional cardiovascular risk factors, metabolic syndrome was significantly associated with carotid atherosclerotic plaques （odds ratio.. 3.36, 95% CI, 1.02 - 11.13, P--0. 047）. Conclusion The prevalence of metabolic syndrome has reached 82.7 % in type 2 diabetes inpatients in Haimen region of Jiangsu province. Metabolic syndrome is an independent risk factor of carotid atherosclerosis.