1H-吲唑类中间体的合成及表征

Synthesis and Characterization of Novel 1H-Indazole Derivatives

以取代邻甲苯胺为原料经乙酰化、溴化、环合及胺解反应得到1H-吲唑类化合物,再与酸酐、碘乙烷或硝酸反应以较高收率合成了15个1H-吲唑衍生物,其中12个未见文献报道。其结构经1H NMR、IR表征确认。

Fifteen 1H-indazole derivatives were prepared in several steps starting from substituted o-toluidine,among which twelve compounds were firstly reported herein. The structures of the products were characterized by1H NMR and IR spectra.