酚妥拉明治疗室间隔缺损合并肺动脉高压的临床意义

Evaluation of Regitine for Patients with Ventricular Septal Defect Associated with Pulmonary Hypertension.

目的 探讨酚妥拉明对治疗室间隔缺损合并重度肺动脉高压的临床意义。 方法 33例室间隔缺损合并重度肺动脉高压患者应用彩色多普勒超声心动图检测静脉注射酚妥拉明后肺动脉收缩压 (PASP)的变化。根据静脉注射酚妥拉明后肺动脉收缩压下降程度不同分为 A组和 B组。 A组 :2 1例 ,肺动脉收缩压下降≥ 2 .6 7k Pa(2 0mm Hg) ;B组 :12例 ,肺动脉收缩压下降 <2 .6 7k Pa(2 0 mm Hg)。比较两组术后低心排血量综合征、心律失常、死亡例数等。 结果 两组肺动脉收缩压均下降 ,A组肺动脉收缩压下降明显 ,其手术疗效好于 B组。A组术后发生低心排血量综合征和心律失常较 B组低 (P<0 .0 5 )。

Objective\ To evaluate the effect of regitine on surgical outcome in patients with ventricular septal defect associated with pulmonary hypertension.\ Methods\ Intravenous injecting regitine, pulmonary artery systolic pressure(PASP) was detected by color Doppler echocardiography in 33 patients with ventricular septal defect. According to patient's pulmonary artery systolic pressure descending degree, the patients were divided into two groups. Group A:21 patients, pulmonary artery systolic pressure descending degree more than 2.67kPa(20 mmHg), group B:12 patients, pulmonary artery systolic pressure descending less than 2.67 kPa(20 mmHg). Clinical operative treatment results were compared between two groups.\ Results\ Pulmonary artery systolic pressure descended in two groups. It was obvious in group A, so there was a good operative result.Low cardiac output syndrome, arrhythmic were more frequent in group B. Statistical analysis were significant between two groups ( P<0.05) .\ Conclusion\ Regitine is useful to evaluate the result and prognosis of surgical operation to ventricular septal defect associated with pulmonary hypertension.