哈尼族验方“莫那奇”对脑出血大鼠行为学和脑水肿的影响

Influence of Monaqi Prescription of Hani Nationality on Behavior and Cerebral Edema in Rats with Experimental Intracerebral Hemorrhage

目的:研究哈尼族验方"莫那奇"对大鼠脑出血(ICH)后行为学和脑水肿的干预作用。方法:将40只SD大鼠随机分为正常组、假手术组、模型组和莫那奇汤组,应用自体血注入法建立大鼠ICH模型,干预后采用Berderson评分评定行为学变化、干/湿重法测定脑含水量。结果:与模型组比较,莫那奇汤组大鼠行为学、大鼠脑水肿好转明显,差异均有统计学意义(P<0.05或P<0.01)。结论:哈尼族验方"莫那奇"可以改善ICH大鼠的行为学和脑水肿程度。

Objective： To study the intervention of Monaqi prescription of Hani nationality on behavior and cerebral edema after experimental intracerebral hemorrhage （ICH） in rats. Methods： The 40 rats were divided into normal control group, sham operated group, ICH model group and Monaqi group. The ICH model was established according to the method of injecting au-tologous blood; Berderson score was applied to evaluate behavioral change and the dry/wet weight method was used to check up cerebral water content after the intervention. Results：Compared to the ICH model group, the behavior and cerebral edema of rats in Monaqi group showed statistics significanee （P〈0.05 or P〈0.01 ）. Conclusion： The Monaqi prescription of Hani na-tionality can ameliorate the behavior and cerebral edemathe of the experimental ICH rats.