慢性乙型病毒性肝炎中医虚实辨证的分子生物学研究概述

Overview of molecular biology research on differentiation of TCM syndroms of deficiency and excess on chronic hapatitis B

中医药对慢性乙型病毒性肝炎(慢乙肝)治疗已积累了丰富的经验,而邪实正虚是中医临床慢性乙型病毒性肝炎基本病机特点,在传统中医四诊辨证的基础上,将现代分子生物学理论及技术与慢乙肝中医虚实辨证相结合,通过比较慢乙肝中医常见虚证与实证之间在乙肝病毒基因型及变异、人类白细胞抗原等位基因多态性、以及转录组、蛋白组学等系统生物学等方面分子生物学领域的差异性,揭示慢乙肝虚实证型之间分子生物学意义,为慢乙肝的中医临床辨证分型和个体化治疗提供新的参考依据,同时也为中医慢乙肝辨证客观化和药物作用机制研究奠定基础。

Traditional Chinese medicine （TCM） has accumulated rich experience in the aspect of treating chronic hepatitis B , and the pathological basis of chronic hepatitis B （CHB） is excessive evil qi and deficient vital qi in TCM clinical practice. Based on the four diagnostic methods of TCM, this research eombines the molecular biologyg theory and techniques, and the deficiency and excess syndrome differentiation, through comparing CHB molecular biology difference between the deficiency and excess syndromes in the aspects of hepatitis B virus （HBV） genotypes and variations, human leukocyte antigen（HLA） alleles polymorphism and systems biology, it reveals the molecular biology meaning, and it provides the scientific foundation of CHB＇s TCM syndrome differentiation and individual therapy, and it will also lay the founda- tion for the study of the obiection of syndrome classification in TCM and the mechanisms of drug effect.