摘要
Dear Editor,We report the results of cloning,expression,subcellular localization analysis,and molecular properties of the Epstein-Barr virus (EBV) BFRF3 gene,using several bioinformatics tools.Bioinformatics analysis indicated that the encoding protein of EBV BFRF3 gene (designated BFRF3) has a conserved Herpes_capsid domain,which was found to be closely related to the gammaherpesvirus capsid protein family,and is highly conserved among its counterparts.Multiple nucleic acid sequence and amino acid (aa) sequence alignments suggested that BFRF3 has a relatively higher
We report the results of cloning,expression,subcellular localization analysis,and molecular properties of the Epstein-Barr virus （EBV） BFRF3 gene,using several bioinformatics tools.Bioinformatics analysis indicated that the encoding protein of EBV BFRF3 gene （designated BFRF3） has a conserved Herpes_capsid domain,which was found to be closely related to the gammaherpesvirus capsid protein family,and is highly conserved among its counterparts.
基金
supported by grants from Science andTechnology New Star in Zhu Jiang,Guangzhou City(2013J2200018)
the Natural Science Foundation ofGuangdong Province(S2013040016596)
the National Natural Science Foundation of China(31200120)
the Medical Scientific Research Foundation of Guangdong Province,China(B2012165)
the Foundation for Distinguished Young Talents in Higher Education of Guangdong,China First Batch of Young Core Instructor of Guangzhou Medical University
the Science and Technology Found ationfor Universities in Guangzhou,China(10A173 and08A097)
the Students’ Extracurricular ScientificAnd Technological Activities in Guangzhou Medical University (2012A039 and 2012C007)
We thank Dr.Teru Kanda for the generous gift of Akata-derivedEBV-BAC
