芳维甲酸乙醇对DMBA/巴豆油诱发小鼠皮肤乳头状瘤化学预防作用的研究

Study on Chemopreventive Effect of Arotinoid Ethylster on DMBA/Corton Oil - Induced Papillomas of The Skin of Mice

目的探讨芳维甲酸乙酯肿瘤预防的作用及机理。方法以 ＤＭＢＡ／巴豆油诱发小鼠皮肤乳头状瘤同时予芳维甲酸乙酯口服。结果第 １４０天时，服药各剂量组小鼠皮肤乳头状瘤的诱发率、每鼠平均瘤数目、平均潜伏期和对照组比较均有显著性差异，并与表皮的细胞凋亡相关。结论芳维甲酸乙酯对肿瘤有预防作用，机理与诱导细胞凋亡相关。

Objective To investigate the chemopreventive effect of arotinoid ethylster and its mechanism. Mathods Skin papillomas were induced in mice by using DMBA and corton. Arotinoid ethylester was orally applied. Results The number of skin papillomas was counted 140 days later, Apoptosis and the expression of related genes were examined. On day 140,of the incidences of papillomas, the average latency period and the average papillomas papillomas numbers of each mouse, the differences between the arotinoid ethylester treated - groups and the control group were significant and related with apoptosis of epidermis. Conclusions Arotinoid ethylester had evidently preventive effects on the tumor, induction of apoptosis of epidermal keratinocytes might play important role in its mechanism.