早期康复训练对局灶性脑梗死大鼠脑水肿的影响

Effect of Early Rehabilitation Training on Cerebral Edema in Middle Cerebral Artery Occlusion Rats

目的研究局灶性脑缺血大鼠脑水肿的变化规律及康复训练对脑水肿的影响。方法 120只雄性Sprague-Dawley脑缺血模型大鼠随机分为正常对照组(n=24)、自然恢复组(n=24)、静息+自然喂养组(n=24)、静息+自然喂养+营养组(n=24)和康复组(n=24)。于第1、3、5、7天进行神经功能评分,应用干-湿重法测定脑组织含水量。结果第1、3、5天,各组大鼠神经功能评分组内和组间比较均无显著性差异(P>0.05)。第7天,除正常对照组外,康复组明显好于其他各组(P<0.01)。第5、7天时,除正常对照组外,康复组大鼠脑水肿降低最快,自然恢复组居中,其他三组最慢。结论康复训练可促进局灶性脑缺血大鼠神经功能恢复,减轻脑水肿。

Objective To study the regularity of cerebral edema in middle cerebral artery occlusion rats and the influence of rehabilita- tion training on edema. Methods 120 male Spragne-Dawley rats were randomly assigned to normal control group （n=24）, no-intervention group （n=24）, resting plus natural feeding group （n=24）, resting plus natural feeding and special nutrition group （n=24）, and training group （n=24）. Bederson score was used to evaluate the neurological function, and the dry-wet weight way was used to measure brain water content on the 1 st day, 3rd day, 5th day, and 7th day. Results There was no significant difference in the other 4 groups except the normal group on the 1st day, 3rd day, and 5th day （P〉0.05）. However, neurological function in the training group was better than that in the other 3 groups ex- cept the normal control group on the 7th day （P〈0.01）. Except the normal control group, the brain water content decreased most rapidly in the training group and slowest in the resting groups after the 3rd day. Conclusion Rehabilitation training could accelerate the recovery of neurological function and release cerebral edema in rats with focal cerebral ischemia.