汉语失语症患者语言康复治疗前后N400变化的研究

Study on Event-related Potential N400 before and after Speech Therapy in Chinese Aphasia Patients

目的观察和分析汉语失语症患者语言康复治疗前后事件相关电位N400波幅和潜伏期变化的特征和规律。方法 20例汉语失语症患者接受规范语言康复治疗,治疗前后采用西方失语症成套测验(WAB)评估患者的语言功能,电生理检查记录N400波幅和潜伏期。结果经12周治疗后,WAB中自发言语、复述、命名及失语商(AQ)积分较治疗前增加(P<0.05);N400潜伏期较治疗前缩短,波幅较治疗前降低(P<0.05)。治疗前后,N400潜伏期、波幅差值与AQ积分差值均呈负相关(P<0.001)。结论 N400能反映汉语失语症患者在语言康复治疗前后语言功能的改善情况,可以作为语言功能恢复的电生理指标。

Objective To investigate the feature of event-related potential N400 before and after speech therapy in Chinese aphasia pa- tients. Methods 20 Chinese aphasia patients received speech therapy for 12 weeks. Language function was evaluated with Western Aphasia Battery （WAB）, and the latency and amplitude of N400 were monitored before and after treatment. Results Spontaneous speech, retelling, and nomination in WAB and aphasia quotient （AQ） of WAB significantly increased after treatment （P〈0.05）. N400 latency was shorter and N400 amplitude was lower after treatment （P〈0.05）. The latency and amplitude of N400 were negatively correlated to the score of AQ in the difference before and after treatment （P〈0.001）. Conclusion Event-related potential N400 could reflect the improvement of speech function before and after treatment, and it is a valuable index for evaluating the recovery of language function in Chinese aphasia patients.